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Neutrophil-To-Lymphocyte and Platelet-To-Lymphocyte Ratios as Prognostic Markers of Survival in Patients with Head and Neck Tumours—Results of a Retrospective Multicentric Study

Author

Listed:
  • Zsuzsanna Szilasi

    (Department of Otorhinolaryngology and Head and Neck Surgery, HDF Medical Centre, H-1134 Budapest, Hungary)

  • Valéria Jósa

    (Department of Otorhinolaryngology and Head and Neck Surgery, Jahn Ferenc Hospital, H-1204 Budapest, Hungary)

  • Zsombor Zrubka

    (Department of Health Economics, Corvinus University of Budapest, H-1093 Budapest, Hungary)

  • Tünde Mezei

    (Department of Urology, Jahn Ferenc Hospital, H-1204 Budapest, Hungary)

  • Tamás Vass

    (Department of Surgery, Szent Imre Hospital, H-1115 Budapest, Hungary)

  • Keresztély Merkel

    (Department of Surgery, Szent Imre Hospital, H-1115 Budapest, Hungary)

  • Frigyes Helfferich

    (Department of Otorhinolaryngology and Head and Neck Surgery, HDF Medical Centre, H-1134 Budapest, Hungary)

  • Zsolt Baranyai

    (1st Department of Surgery, Semmelweis University, H-1082 Budapest, Hungary)

Abstract

Background: The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) may be useful for drawing conclusions about the survival of head and neck squamous cell carcinoma (HNSCC) patients. Methods: Clinical data of 156 patients managed for HNSCC at two head and neck surgery centres were analyzed retrospectively. We studied the relationships between survival and PLR as well as NLR. Results: With regards to 5-year survival, the difference between the two groups with PLR values lower or higher than the threshold was statistically significant ( p = 0.004), and we found the same for disease-free survival ( p = 0.05), and tumour-specific mortality ( p = 0.009). Concerning NLR, the difference in tumour-specific survival was statistically significant ( p = 0.006). According to the multivariate analysis, NLR values higher than the threshold indicated an enhanced risk for overall as well as for tumour-specific mortality. Conclusion: In HNSCC patients, a high NLR may be considered as an independent risk factor for 5-year overall survival.

Suggested Citation

  • Zsuzsanna Szilasi & Valéria Jósa & Zsombor Zrubka & Tünde Mezei & Tamás Vass & Keresztély Merkel & Frigyes Helfferich & Zsolt Baranyai, 2020. "Neutrophil-To-Lymphocyte and Platelet-To-Lymphocyte Ratios as Prognostic Markers of Survival in Patients with Head and Neck Tumours—Results of a Retrospective Multicentric Study," IJERPH, MDPI, vol. 17(5), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1742-:d:329663
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    References listed on IDEAS

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    1. Zhengshui Xu & Wei Xu & Hua Cheng & Wei Shen & Jiaqi Ying & Fei Cheng & Wenji Xu, 2016. "The Prognostic Role of the Platelet-Lymphocytes Ratio in Gastric Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-11, September.
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