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Periodontal Condition Is Correlated with Deep and Subcortical White Matter Hyperintensity Lesions in Japanese Adults

Author

Listed:
  • Minako Hada

    (Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho, Gifu 501-0296, Japan)

  • Tetsuji Azuma

    (Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho, Gifu 501-0296, Japan)

  • Koichiro Irie

    (Department of Oral Health and Preventive Dentistry, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan)

  • Takatoshi Yonenaga

    (Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho, Gifu 501-0296, Japan)

  • Kazutoshi Watanabe

    (Asahi University Hospital, 3- 23 Hashimoto-cho, Gifu, Gifu 500-8523, Japan)

  • Fumiko Deguchi

    (Asahi University Hospital, 3- 23 Hashimoto-cho, Gifu, Gifu 500-8523, Japan)

  • Akihiro Obora

    (Asahi University Hospital, 3- 23 Hashimoto-cho, Gifu, Gifu 500-8523, Japan)

  • Takao Kojima

    (Asahi University Hospital, 3- 23 Hashimoto-cho, Gifu, Gifu 500-8523, Japan)

  • Takaaki Tomofuji

    (Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho, Gifu 501-0296, Japan)

Abstract

Deep and subcortical white matter hyperintensity (DSWMH) lesions are a small-vessel disease of the brain. The aim of this cross-sectional study was to investigate the relationship between DSWMH lesions and periodontal status in Japanese adults who participated in a health check. We enrolled 444 consecutive participants (mean age, 54.5 years) who received both brain and oral health evaluation services at the Asahi University Hospital. Magnetic resonance imaging was used to detect DSWMH lesions. Periodontal status was assessed using the community periodontal index. Of the study participants, 215 (48.4%) had DSWMH lesions. Multivariate logistic regression showed that the presence of DSWMH lesions was significantly related to age ≥ 65 years (vs. < 65 years, odds ratio [OR] = 2.984, 95% confidence interval [CI] = 1.696–5.232), systolic blood pressure ≥ 140 mmHg (vs. < 140 mmHg, OR = 2.579, 95% CI = 1.252–5.314), the presence of ≥ 28 teeth (vs. < 28 teeth, OR = 0.635, 95% CI = 0.420–0.961), and probing pocket depth (PPD) ≥ 6 mm (vs. PPD < 6 mm, OR = 1.948, 95% CI = 1.132–3.354) after adjustment for confounding factors. Having PPD ≥ 6 mm may be a risk factor for DSWMH lesions in Japanese adults.

Suggested Citation

  • Minako Hada & Tetsuji Azuma & Koichiro Irie & Takatoshi Yonenaga & Kazutoshi Watanabe & Fumiko Deguchi & Akihiro Obora & Takao Kojima & Takaaki Tomofuji, 2020. "Periodontal Condition Is Correlated with Deep and Subcortical White Matter Hyperintensity Lesions in Japanese Adults," IJERPH, MDPI, vol. 17(5), pages 1-10, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1694-:d:328736
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    References listed on IDEAS

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    1. Andreia M. R. Cardoso & Lays N. Gomes & Clara Regina D. Silva & Renata De S. C. Soares & Mauro Henrique N. G. De Abreu & Wilton W. N. Padilha & Alessandro L. Cavalcanti, 2014. "Dental Caries and Periodontal Disease in Brazilian Children and Adolescents with Cerebral Palsy," IJERPH, MDPI, vol. 12(1), pages 1-19, December.
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