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Formaldehyde, Oxidative Stress, and FeNO in Traffic Police Officers Working in Two Cities of Northern Italy

Author

Listed:
  • Giulia Squillacioti

    (Department of Public Health and Pediatrics, University of Torino, 10121 Torino, Italy)

  • Valeria Bellisario

    (Department of Public Health and Pediatrics, University of Torino, 10121 Torino, Italy)

  • Amelia Grosso

    (Division of Respiratory Diseases, S. Matteo Foundation–University of Pavia, 5001 Pavia, Italy)

  • Federica Ghelli

    (Department of Public Health and Pediatrics, University of Torino, 10121 Torino, Italy)

  • Pavilio Piccioni

    (Unit of Respiratory Medicine, National Health Service, ASL TO2, 10121 Torino, Italy)

  • Elena Grignani

    (Maugeri Scientific Clinical Institutes, 5001 Pavia, Italy)

  • Angelo Corsico

    (Division of Respiratory Diseases, S. Matteo Foundation–University of Pavia, 5001 Pavia, Italy
    These two authors equally contributed to the conception and execution of the study.)

  • Roberto Bono

    (Department of Public Health and Pediatrics, University of Torino, 10121 Torino, Italy
    These two authors equally contributed to the conception and execution of the study.)

Abstract

Personal air formaldehyde (air-FA) was measured as risk factor of airways inflammation and oxidative stress (SO) induction. Overall, 154 police officers were enrolled from two differently urbanised Italian cities, Turin and Pavia. Urinary F2t-isoprostane (15-F2t-IsoP), a prostaglandin-like compound, was quantified as a biomarker of general OS in vivo and fractional exhaled nitric oxide (FeNO) was measured for monitoring local inflammatory processes. Urinary cotinine was quantified as a biomarker of tobacco smoking exposure. Traffic police officers living in Turin showed an increased level of log air-FA ( p < 0.001), equal to +53.6% ( p < 0.001). Log air-(FA) mean values were 3.38 (C.I. 95% 3.33–3.43) and 2.84 (C.I. 95% 2.77–2.92) in Turin and Pavia, respectively. Log (air-FA) was higher in “outdoor workers” (3.18, C.I. 95% 3.13–3.24, p = 0.035) compared to “indoor workers”, showing an increase of +9.3%, even controlling for sex and city. The analyses on 15-F2t-IsoP and FeNO, both adjusted for log air-FA, highlighted that OS and inflammation were higher (+66.8%, p < 0.001 and +75%, p < 0.001, respectively) in Turin traffic police officers compared to those from Pavia. Our findings suggest that even low exposures to traffic-related emissions and urbanisation may influence both general oxidative stress levels and local inflammation.

Suggested Citation

  • Giulia Squillacioti & Valeria Bellisario & Amelia Grosso & Federica Ghelli & Pavilio Piccioni & Elena Grignani & Angelo Corsico & Roberto Bono, 2020. "Formaldehyde, Oxidative Stress, and FeNO in Traffic Police Officers Working in Two Cities of Northern Italy," IJERPH, MDPI, vol. 17(5), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1655-:d:328173
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