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Antibacterial Activity against Staphylococcus Aureus of Titanium Surfaces Coated with Graphene Nanoplatelets to Prevent Peri-Implant Diseases. An In-Vitro Pilot Study

Author

Listed:
  • Nicola Pranno

    (Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, 00100 Rome, Italy)

  • Gerardo La Monaca

    (Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, 00100 Rome, Italy)

  • Antonella Polimeni

    (Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, 00100 Rome, Italy)

  • Maria Sabrina Sarto

    (SNN Lab, Sapienza Nanotechnology & Nano-Science Laboratory, Sapienza, University of Rome, 00100 Rome, Italy
    DIAEE, Department of Astronautical, Electrical, Energy Engineering, Sapienza University of Rome, 00100 Rome, Italy)

  • Daniela Uccelletti

    (BBCD, Department of Biology and Biotechnology, Sapienza University of Rome, 00100 Rome, Italy)

  • Erika Bruni

    (BBCD, Department of Biology and Biotechnology, Sapienza University of Rome, 00100 Rome, Italy)

  • Maria Paola Cristalli

    (Department of Biotechnologies and Medico Surgical Sciences, Sapienza University of Rome, 00100 Rome, Italy)

  • Domenico Cavallini

    (SNN Lab, Sapienza Nanotechnology & Nano-Science Laboratory, Sapienza, University of Rome, 00100 Rome, Italy
    DIAEE, Department of Astronautical, Electrical, Energy Engineering, Sapienza University of Rome, 00100 Rome, Italy)

  • Iole Vozza

    (Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, 00100 Rome, Italy)

Abstract

Dental implants are one of the most commonly used ways to replace missing teeth. Nevertheless, the close contact with hard and soft oral tissues expose these devices to infectious peri-implant diseases. To prevent such infection, several surface treatments have been developed in the last few years to improve the antimicrobial properties of titanium dental implants. In this in-vitro pilot study, the antimicrobial activity of titanium surfaces coated with different types of graphene nanoplatelets are investigated. Six different colloidal suspensions of graphene nanoplatelets (GNPs) were produced from graphite intercalated compounds, setting the temperature and duration of the thermal shock and varying the number of the exfoliation cycles. Titanium disks with sand-blasted and acid-etched surfaces were sprayed with 2 mL of colloidal GNPs suspensions. The size of the GNPs and the percentage of titanium disk surfaces coated by GNPs were evaluated through a field emission-scanning electron microscope. The antibacterial activity of the specimens against Staphylococcus aureus was estimated using a crystal violet assay. The dimension of GNPs decreased progressively after each sonication cycle. The two best mean percentages of titanium disk surfaces coated by GNPs were GNPs 1050°/2 and GNPs 1150°/2 . The reduction of biofilm development was 14.4% in GNPs 1150°/2 , 20.1% in GNPs 1150°/3 , 30.3% in GNPs 1050°/3 , and 39.2% in GNPs 1050°/2 . The results of the study suggested that the surface treatment of titanium disks with GNPs represents a promising solution to improve the antibacterial activity of titanium implants.

Suggested Citation

  • Nicola Pranno & Gerardo La Monaca & Antonella Polimeni & Maria Sabrina Sarto & Daniela Uccelletti & Erika Bruni & Maria Paola Cristalli & Domenico Cavallini & Iole Vozza, 2020. "Antibacterial Activity against Staphylococcus Aureus of Titanium Surfaces Coated with Graphene Nanoplatelets to Prevent Peri-Implant Diseases. An In-Vitro Pilot Study," IJERPH, MDPI, vol. 17(5), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1568-:d:326458
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    Cited by:

    1. Iole Vozza, 2021. "Oral Prevention and Management of Oral Healthcare," IJERPH, MDPI, vol. 18(4), pages 1-3, February.

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