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Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review

Author

Listed:
  • Marco Capece

    (Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy)

  • Massimiliano Creta

    (Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy)

  • Armando Calogero

    (Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy)

  • Roberto La Rocca

    (Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy)

  • Luigi Napolitano

    (Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy)

  • Biagio Barone

    (Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy)

  • Antonello Sica

    (Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy)

  • Ferdinando Fusco

    (Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy)

  • Michele Santangelo

    (Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy)

  • Concetta Dodaro

    (Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy)

  • Caterina Sagnelli

    (Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy)

  • Nicola Carlomagno

    (Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy)

  • Felice Crocetto

    (Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy)

  • Gianluigi Califano

    (Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy)

  • Francesco Mangiapia

    (Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy)

  • Nicola Longo

    (Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy)

Abstract

Background : Prostate cancer (PCa) represents a common disease in men aged >65 years. The role of physical activity (PA) in patients at risk or diagnosed with PCa represents an evolving issue. We aimed to summarize available evidences about the impact of PA on the pathophysiology and clinical outcomes of PCa. Methods : We performed a narrative review. Evidences about the role of PA in elderly patients in terms of PCa biology, epidemiology, oncological and functional outcomes, as well as in terms of impact on the outcomes of androgen deprivation therapy (ADT) were summarized. Results : Potential pathophysiological pathways hypothesized to explain the benefits of PA in terms of prostate carcinogenesis include circulating levels of Insulin-like growth factor-1 (IGF-1), oxidative stress, systemic inflammation, sex hormones, and myokines. Clinically, emerging evidences support the hypothesis that PA is associated with decreased PCa risk, improved PCa-related survival, improved functional outcomes, and reduced ADT-related adverse events.

Suggested Citation

  • Marco Capece & Massimiliano Creta & Armando Calogero & Roberto La Rocca & Luigi Napolitano & Biagio Barone & Antonello Sica & Ferdinando Fusco & Michele Santangelo & Concetta Dodaro & Caterina Sagnell, 2020. "Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review," IJERPH, MDPI, vol. 17(4), pages 1-9, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1441-:d:324299
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    Citations

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    Cited by:

    1. Antonello Sica & Caterina Sagnelli & Alfonso Papa & Massimo Ciccozzi & Evangelista Sagnelli & Armando Calogero & Erika Martinelli & Beniamino Casale, 2020. "An Anecdotal Case Report of Chronic Lymphatic Leukemia with del(11q) Treated with Ibrutinib: Artificial Nourishment and Physical Activity Program," IJERPH, MDPI, vol. 17(6), pages 1-8, March.
    2. Felice Crocetto & Davide Arcaniolo & Luigi Napolitano & Biagio Barone & Roberto La Rocca & Marco Capece & Vincenzo Francesco Caputo & Ciro Imbimbo & Marco De Sio & Francesco Paolo Calace & Celeste Man, 2021. "Impact of Sexual Activity on the Risk of Male Genital Tumors: A Systematic Review of the Literature," IJERPH, MDPI, vol. 18(16), pages 1-17, August.

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