IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i4p1194-d320089.html
   My bibliography  Save this article

Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study

Author

Listed:
  • Francisco M. Peinado

    (Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
    These authors equally contributed to this work.)

  • Inmaculada Lendínez

    (General Surgery, San Cecilio University Hospital, E-18016 Granada, Spain
    These authors equally contributed to this work.)

  • Rafael Sotelo

    (Gynaecology and Obstetrics Unit, ‘San Cecilio’ University Hospital, E-18016 Granada, Spain)

  • Luz M. Iribarne-Durán

    (Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain)

  • Jorge Fernández-Parra

    (Gynaecology and Obstetrics Unit, ‘Virgen de las Nieves’ University Hospital, E-18014 Granada, Spain)

  • Fernando Vela-Soria

    (Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain)

  • Nicolás Olea

    (Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
    CIBER de Epidemiología y Salud Pública (CIBERESP), E-28029 Madrid, Spain
    Radiology and Physical Medicine Department, University of Granada, E-18016 Granada, Spain
    Nuclear Medicine Unit, ‘San Cecilio’ University Hospital, E-18016 Granada, Spain)

  • Mariana F. Fernández

    (Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
    CIBER de Epidemiología y Salud Pública (CIBERESP), E-28029 Madrid, Spain
    Radiology and Physical Medicine Department, University of Granada, E-18016 Granada, Spain)

  • Carmen Freire

    (Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
    CIBER de Epidemiología y Salud Pública (CIBERESP), E-28029 Madrid, Spain)

  • Josefa León

    (Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
    Digestive Medicine Unit, ‘San Cecilio’ University Hospital, E-18012 Granada, Spain
    CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD), E-28029 Madrid, Spain)

  • Beatriz Pérez-Cabrera

    (General Surgery, San Cecilio University Hospital, E-18016 Granada, Spain)

  • Olga Ocón-Hernández

    (Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
    Gynaecology and Obstetrics Unit, ‘San Cecilio’ University Hospital, E-18016 Granada, Spain)

  • Francisco Artacho-Cordón

    (Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
    CIBER de Epidemiología y Salud Pública (CIBERESP), E-28029 Madrid, Spain
    Radiology and Physical Medicine Department, University of Granada, E-18016 Granada, Spain)

Abstract

Aim: The aim of this study was to explore associations of urinary concentrations of bisphenols A (BPA), S (BPS), and F (BPF) and of thiobarbituric acid reactive substances (TBARS) with the risk of endometriosis in women of childbearing age. Methods : This case–control study enrolled 124 women between January 2018 and July 2019: 35 women with endometriosis (cases) and 89 women without endometriosis undergoing abdominal surgery for other reasons (controls). Endometriosis was diagnosed (cases) or ruled out (controls) by laparoscopic inspection of the pelvis and the biopsy of suspected lesions (histological diagnosis). Fasting urine samples were collected before surgery to determine concentrations of BPA, BPS, BPF, and TBARS. Associations of bisphenol and TBARS concentrations with endometriosis risk were explored with multivariate logistic and linear regression analyses. Results: After adjustment for urinary creatinine, age, BMI, parity, and residence, endometriosis risk was increased with each 1 log unit of BPA [OR 1.5; 95%CI 1.0–2.3] and Σbisphenols [OR 1.5; 95%CI 0.9–2.3] but was not associated with the presence of BPS and BPF. Classification of the women by tertiles of exposure revealed statistically significant associations between endometriosis risk and the second tertile of exposure to BPA [OR 3.7; 95%CI 1.3–10.3] and Σbisphenols [OR 5.4; 95%CI 1.9–15.6]. In addition, TBARS concentrations showed a close-to-significant relationship with increased endometriosis risk [OR 1.6; 95%CI 1.0–2.8], and classification by TBARS concentration tertile revealed that the association between endometriosis risk and concentrations of BPA [OR 2.0; 95%CI 1.0–4.1] and Σbisphenols [OR 2.2; 95%CI 1.0–4.6] was only statistically significant for women in the highest TBARS tertile (>4.23 μM). Conclusion : Exposure to bisphenols may increase the risk of endometriosis, and oxidative stress may play a crucial role in this association. Further studies are warranted to verify these findings.

Suggested Citation

  • Francisco M. Peinado & Inmaculada Lendínez & Rafael Sotelo & Luz M. Iribarne-Durán & Jorge Fernández-Parra & Fernando Vela-Soria & Nicolás Olea & Mariana F. Fernández & Carmen Freire & Josefa León & B, 2020. "Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study," IJERPH, MDPI, vol. 17(4), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1194-:d:320089
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/4/1194/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/4/1194/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. I-Jen Wang & Wilfried J. J. Karmaus, 2017. "Oxidative Stress-Related Genetic Variants May Modify Associations of Phthalate Exposures with Asthma," IJERPH, MDPI, vol. 14(2), pages 1-14, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1194-:d:320089. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.