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Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Author

Listed:
  • Lidia Caporossi

    (National Institute of Insurance against Accidents at Work-Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 00078 Monte Porzio Catone, Italy)

  • Alessandra Alteri

    (Unit of Obstetrics and Gynecology, San Raffaele Scientific Institute, 20132 Milan, Italy)

  • Giovanni Campo

    (Unit of Obstetrics and Gynecology, San Raffaele Scientific Institute, 20132 Milan, Italy)

  • Enrico Paci

    (National Institute of Insurance against Accidents at Work-Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 00078 Monte Porzio Catone, Italy)

  • Giovanna Tranfo

    (National Institute of Insurance against Accidents at Work-Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 00078 Monte Porzio Catone, Italy)

  • Silvia Capanna

    (National Institute of Insurance against Accidents at Work-Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 00078 Monte Porzio Catone, Italy)

  • Enrico Papaleo

    (Unit of Obstetrics and Gynecology, San Raffaele Scientific Institute, 20132 Milan, Italy)

  • Daniela Pigini

    (National Institute of Insurance against Accidents at Work-Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 00078 Monte Porzio Catone, Italy)

  • Paola Viganò

    (Reproductive Sciences Laboratory, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milan, Italy)

  • Bruno Papaleo

    (National Institute of Insurance against Accidents at Work-Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 00078 Monte Porzio Catone, Italy)

Abstract

Among the possible risk factors for male reproduction, exposure to phthalates and alkylphenols is widely documented. This study evaluated the possible association between chemical exposure and the quality of the seminal fluid of 105 subjects in a fertility clinic. The urinary levels of seven phthalate metabolites (monoethylphthalate, MEP; monobenzylphthalate, MBzP; mono n -butylphthalate, MnBP; mono-(2-ethylhexyl) phthalate, MEHP; mono(2-ethyl-5-hydroxyhexyl) phthalate, MEHHP; mono- n -octylphthalate, MnOP; mono-isononylphthalate, MiNP) and bisphenol A (BPA), were analysed by high performance liquid chromatography/tandem mass spectrometry HPLC/MS/MS. The regression analysis showed that the semen volume was positively associated with MnBP, MnOP and BPA levels while was negatively associated with MiNP levels. The sperm concentration had a significant inverse relationship with MEP levels. A negative association was found between the use of plastic containers for food storage ( p = 0.037) and semen volume (3.06 vs. 2.30 mL as average values, never vs daily). A significant positive correlation emerged ( p < 0.005) between the consumption of canned food and the levels of BPA (2.81 vs. 0.14 µg/g creat as average values, daily vs. never) and between the use of perfumes and levels of MEP (389.86 vs. 48.68 µg/g creat, as average values, daily vs. never). No further statistically significant associations were found, even considering the working activity. Some evidence emerged about the possible link between exposure and seminal fluid quality: further case/control or prospective studies will allow us to confirm this causality hypothesis.

Suggested Citation

  • Lidia Caporossi & Alessandra Alteri & Giovanni Campo & Enrico Paci & Giovanna Tranfo & Silvia Capanna & Enrico Papaleo & Daniela Pigini & Paola Viganò & Bruno Papaleo, 2020. "Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center," IJERPH, MDPI, vol. 17(2), pages 1-18, January.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:2:p:489-:d:308038
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    Citations

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    Cited by:

    1. Lidia Caporossi & Paola Viganò & Enrico Paci & Silvia Capanna & Alessandra Alteri & Daniela Pigini & Giovanna Tranfo & Bruno Papaleo, 2022. "A Case–Control Study on the Effects of Plasticizers Exposure on Male Fertility," IJERPH, MDPI, vol. 20(1), pages 1-14, December.
    2. Thea Emily Benson & Anne Gaml-Sørensen & Andreas Ernst & Nis Brix & Karin Sørig Hougaard & Katia Keglberg Hærvig & Jens Peter Ellekilde Bonde & Sandra Søgaard Tøttenborg & Christian H. Lindh & Cecilia, 2021. "Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men," IJERPH, MDPI, vol. 18(4), pages 1-12, February.
    3. Angela Giuliani & Mariachiara Zuccarini & Angelo Cichelli & Haroon Khan & Marcella Reale, 2020. "Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact," IJERPH, MDPI, vol. 17(16), pages 1-43, August.
    4. Stefania D'Angelo & Rosaria Meccariello, 2021. "Microplastics: A Threat for Male Fertility," IJERPH, MDPI, vol. 18(5), pages 1-11, March.

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