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Mouse Mammary Tumor Virus (MMTV)-Like env Sequence in Brazilian Breast Cancer Samples: Implications in Clinicopathological Parameters in Molecular Subtypes

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Listed:
  • Nathália de Sousa Pereira

    (Laboratory of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, PR 86057-970, Brazil)

  • Glauco Akelinghton Freire Vitiello

    (Laboratory of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, PR 86057-970, Brazil)

  • Bruna Karina Banin-Hirata

    (Laboratory of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, PR 86057-970, Brazil)

  • Glaura Scantamburlo Alves Fernandes

    (Department of General Biology, Biological Sciences Center, Londrina State University, Londrina, PR 86057-970, Brazil)

  • Maria José Sparça Salles

    (Department of General Biology, Biological Sciences Center, Londrina State University, Londrina, PR 86057-970, Brazil)

  • Marla Karine Amarante

    (Laboratory of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, PR 86057-970, Brazil)

  • Maria Angelica Ehara Watanabe

    (Laboratory of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, PR 86057-970, Brazil)

Abstract

Background: Breast cancer (BC) is a complex disease in which susceptibility and clinical course depend on multiple factors. Evidence suggests that a mouse mammary tumor virus (MMTV)-homolog may be present in human BCs; however, little is known about its clinical implications. Methods: MMTV-like env nucleotide-sequence was searched in tumor and tumor-adjacent tissues from 217 Brazilian BC patients through nested-PCR and confirmed through PCR-sequencing. Blood samples were also tested for patients with MMTV-like env gene-positive tumors. Correlations with clinicopathological parameters were evaluated. Results: MMTV-like env sequence was detected in tumor and tumor-adjacent tissue samples from 41/217 and 30/196 patients, respectively. In blood, MMTV-like was detected in 17/32 patients. In Luminal-B tumors, MMTV-like in tumor tissue was negatively correlated with tumor size and disease stage, whereas in HER2 tumors it anti-correlated with lymph node metastasis (LNM) and disease stage. Considering blood, MMTV-like env gene positivity negatively correlated with age in general BC, while in Luminal-A tumors it positively correlated with Ki67 but negatively correlated with age and LNM. The associations with decreased LNM frequency were independent of other prognostic factors. Conclusion: MMTV-like env positivity is associated with better prognostic parameters in BC subtypes, which might be explainable by its anti-metastatic potential and by putative activation of immune milieu.

Suggested Citation

  • Nathália de Sousa Pereira & Glauco Akelinghton Freire Vitiello & Bruna Karina Banin-Hirata & Glaura Scantamburlo Alves Fernandes & Maria José Sparça Salles & Marla Karine Amarante & Maria Angelica Eha, 2020. "Mouse Mammary Tumor Virus (MMTV)-Like env Sequence in Brazilian Breast Cancer Samples: Implications in Clinicopathological Parameters in Molecular Subtypes," IJERPH, MDPI, vol. 17(24), pages 1-14, December.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:24:p:9496-:d:464350
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    References listed on IDEAS

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    1. Yu Kong & Christopher M. Rose & Ashley A. Cass & Alexander G. Williams & Martine Darwish & Steve Lianoglou & Peter M. Haverty & Ann-Jay Tong & Craig Blanchette & Matthew L. Albert & Ira Mellman & Rich, 2019. "Transposable element expression in tumors is associated with immune infiltration and increased antigenicity," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
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