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Temporal Association between Topical Ophthalmic Corticosteroid and the Risk of Central Serous Chorioretinopathy

Author

Listed:
  • Yuh-Shin Chang

    (Department of Ophthalmology, Chi Mei Medical Center, Tainan 710, Taiwan
    Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan)

  • Shih-Feng Weng

    (Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
    Center for Medical informatics and Statistics, Office of R&D, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

  • Jhi-Joung Wang

    (Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan
    Department of Anesthesiology, Chi Mei Medical Center, Tainan 710, Taiwan
    AI Biomed Center, Southern Taiwan University of Science and Technology, Tainan 710, Taiwan)

  • Ren-Long Jan

    (Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan
    Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan)

Abstract

This retrospective, nationwide, matched cohort study investigated the temporal relationship of central serous chorioretinopathy (CSCR) following topical ophthalmic corticosteroid (TOC) use. Using the Longitudinal Health Insurance Database 2000 (LHID2000), we collected patients diagnosed with CSCR between January 2001 and December 2010 ( n = 2921) and a control group ( n = 17,526). Information for each patient was collected and tracked from the index date until December 2011. TOC users were classified based on (i) the date of the last prescription before diagnosis: current users (≤30 days) and former users (31–182 days and ≥183 days) and (ii) the prescription refill intervals: persistent users (interval ≤90 days) and non-persistent users (interval >90 days). The odds ratio (OR) was estimated from multivariate conditional logistic regression after adjusting for relevant confounders. After adjusting for age, sex, geographic region, index date, previously known comorbidities, the date of last TOC prescription before diagnosis, or prescription refilling intervals, the results revealed that patients were likely to have developed CSCR while using TOCs currently (OR = 30.42, 95% CI = 25.95–35.66, p < 0.001) and persistently (OR = 7.30, 95% CI = 6.13–8.69, p < 0.001) as compared to the controls. Our results indicate that current or persistent TOCs use increases the risk of CSCR. Thus, patients requiring TOCs should be advised of this risk, particularly in current or persistent use conditions.

Suggested Citation

  • Yuh-Shin Chang & Shih-Feng Weng & Jhi-Joung Wang & Ren-Long Jan, 2020. "Temporal Association between Topical Ophthalmic Corticosteroid and the Risk of Central Serous Chorioretinopathy," IJERPH, MDPI, vol. 17(24), pages 1-11, December.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:24:p:9455-:d:463685
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