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INSIDE Project: Individual Air Pollution Exposure, Extracellular Vesicles Signaling and Hypertensive Disorder Development in Pregnancy

Author

Listed:
  • Luca Ferrari

    (EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Francesca Borghi

    (Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy)

  • Simona Iodice

    (EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Dolores Catelan

    (Department of Statistics, Computer Science and Applications “G. Parenti”, Università degli Studi di Firenze, 50134 Florence, Italy)

  • Stefano Rossi

    (Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy)

  • Ilaria Giusti

    (Department of Life, Health and Environmental Sciences, Università degli Studi dell’Aquila, 67100 L’Aquila, Italy)

  • Laura Grisotto

    (Department of Statistics, Computer Science and Applications “G. Parenti”, Università degli Studi di Firenze, 50134 Florence, Italy)

  • Sabrina Rovelli

    (Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy)

  • Andrea Spinazzè

    (Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy)

  • Rossella Alinovi

    (Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy)

  • Silvana Pinelli

    (Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy)

  • Laura Cantone

    (EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Laura Dioni

    (EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Benedetta Ischia

    (Department of Obstetrics and Gynecology ‘L. Mangiagalli’, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy)

  • Irene Rota

    (Cardiovascular Disease Unit, Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy)

  • Jacopo Mariani

    (EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Federica Rota

    (EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Mirjam Hoxha

    (EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Giorgia Stoppa

    (Department of Statistics, Computer Science and Applications “G. Parenti”, Università degli Studi di Firenze, 50134 Florence, Italy)

  • Damiano Monticelli

    (Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy)

  • Domenico Cavallo

    (Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy)

  • Enrico Bergamaschi

    (Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy
    Department of Public Health Sciences and Pediatrics, Università di Torino, 10126 Turin, Italy)

  • Marco Vicenzi

    (Cardiovascular Disease Unit, Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
    Dyspnea Lab, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Nicola Persico

    (Department of Obstetrics and Gynecology ‘L. Mangiagalli’, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
    Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

  • Annibale Biggeri

    (Department of Statistics, Computer Science and Applications “G. Parenti”, Università degli Studi di Firenze, 50134 Florence, Italy
    These authors contribute equally to this work.)

  • Andrea Cattaneo

    (Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy
    These authors contribute equally to this work.)

  • Vincenza Dolo

    (Department of Life, Health and Environmental Sciences, Università degli Studi dell’Aquila, 67100 L’Aquila, Italy
    These authors contribute equally to this work.)

  • Michele Miragoli

    (Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy
    These authors contribute equally to this work.)

  • Paola Mozzoni

    (Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy
    These authors contribute equally to this work.)

  • Valentina Bollati

    (EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy)

Abstract

Hypertensive disorders are common complications during pregnancy (HDP) with substantial public health impact. Acute and chronic particulate matter (PM) exposure during pregnancy increases the risk of HDP, although the underlying molecular mechanisms remain unclear. Extracellular vesicles (EVs) may be the ideal candidates for mediating the effects of PM exposure in pregnancy as they are released in response to environmental stimuli. The INSIDE project aims to investigate this mechanism in pregnancy outcomes. The study population is enrolled at the Fetal Medicine Unit of Fondazione IRCCS Ca’Granda—Ospedale Maggiore Policlinico at 10–14 weeks of gestation. Exposure to PM 10 and PM 2.5 is assessed using the flexible air quality regional model (FARM) and Bayesian geostatistical models. Each woman provides a blood sample for EV analysis and circulating biomarker assessment. Moreover, a subgroup of recruited women (n = 85) is asked to participate in a cardiovascular screening program including a standard clinical evaluation, a non-invasive assessment of right ventricular function, and pulmonary circulation at rest and during exercise. These subjects are also asked to wear a personal particulate sampler, to measure PM 10 , PM 2.5 , and PM 1 . The INSIDE study is expected to identify the health impacts of PM exposure on pregnancy outcomes.

Suggested Citation

  • Luca Ferrari & Francesca Borghi & Simona Iodice & Dolores Catelan & Stefano Rossi & Ilaria Giusti & Laura Grisotto & Sabrina Rovelli & Andrea Spinazzè & Rossella Alinovi & Silvana Pinelli & Laura Cant, 2020. "INSIDE Project: Individual Air Pollution Exposure, Extracellular Vesicles Signaling and Hypertensive Disorder Development in Pregnancy," IJERPH, MDPI, vol. 17(23), pages 1-14, December.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:23:p:9046-:d:456720
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