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Estimates of Cancer Mortality Attributable to Carcinogenic Infections in Italy

Author

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  • Pietro Ferrara

    (Center for Public Health Research, University of Milan—Bicocca, 20900 Monza, Italy)

  • Sara Conti

    (Center for Public Health Research, University of Milan—Bicocca, 20900 Monza, Italy
    Value-Based Healthcare Unit, IRCCS Multi Medica, 20099 Sesto San Giovanni, Italy)

  • Fernando Agüero

    (Preventive Medicine Department, University Hospital of Bellvitge—IDIBELL, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
    Clinical Science Department, University of Barcelona, L’Hospitalet de Llobregat, 08907 Barcelona, Spain)

  • Luciana Albano

    (Department of Experimental Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy)

  • Cristina Masuet-Aumatell

    (Preventive Medicine Department, University Hospital of Bellvitge—IDIBELL, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
    Clinical Science Department, University of Barcelona, L’Hospitalet de Llobregat, 08907 Barcelona, Spain)

  • Josep Maria Ramon-Torrell

    (Preventive Medicine Department, University Hospital of Bellvitge—IDIBELL, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
    Clinical Science Department, University of Barcelona, L’Hospitalet de Llobregat, 08907 Barcelona, Spain)

  • Lorenzo Giovanni Mantovani

    (Center for Public Health Research, University of Milan—Bicocca, 20900 Monza, Italy
    Value-Based Healthcare Unit, IRCCS Multi Medica, 20099 Sesto San Giovanni, Italy)

Abstract

Several infectious agents are ascertained causes of cancer, but the burden of cancer mortality attributable to carcinogenic infections in Italy is still unknown. To tackle this issue, we calculated the rate and regional distribution of cancer deaths due to infections sustained by seven pathogens ranked as group 1 carcinogenic agents in humans by the International Agency for Research on Cancer. Population attributable fractions related to these agents were applied to annual statistics of cancer deaths coded according to the 10th International Classification of Diseases. The estimated burden of cancer mortality attributable to carcinogenic infections in Italy during the period 2011–2015 was 8.7% of all cancer deaths registered yearly, on average. Approximately 60% of deaths occurred in men, and almost the whole burden was due to four infectious agents ( Helicobacter pylori , hepatitis C virus, high-risk human papillomavirus, and hepatitis B virus). The analysis of regional distribution showed a higher number of infection-related cancer deaths in the northern regions, where the estimates reached 30 (Liguria) and 28 (Friuli Venezia Giulia) deaths per 100,000 inhabitants in 2015. Since one-twelfth of cancer deaths were attributable to these modifiable risk factors, the implementation of appropriate prevention and treatment interventions may help to reduce the impact of these infections on cancer mortality.

Suggested Citation

  • Pietro Ferrara & Sara Conti & Fernando Agüero & Luciana Albano & Cristina Masuet-Aumatell & Josep Maria Ramon-Torrell & Lorenzo Giovanni Mantovani, 2020. "Estimates of Cancer Mortality Attributable to Carcinogenic Infections in Italy," IJERPH, MDPI, vol. 17(23), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:23:p:8723-:d:450285
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    References listed on IDEAS

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    1. Laura Spagnoli & Antoine Flahault & Pietro Ferrara, 2020. "Migrant Health Burden: Where Do We Stand?," IJERPH, MDPI, vol. 17(9), pages 1-3, April.
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    Cited by:

    1. Daniele Nucci & Vincenza Gianfredi & Pietro Ferrara & Omar Enzo Santangelo & Beatrice Varotto & Alessandra Feltrin & Antonella Galiano & Mariateresa Nardi, 2023. "Association between Malnutrition and Depression in Patients with Cancer: The Importance of Nutritional Status Evaluation in Cancer Care," IJERPH, MDPI, vol. 20(3), pages 1-10, January.
    2. Pietro Ferrara & Luciana Albano, 2022. "Advances in Population-Based Healthcare Research: From Measures to Evidence," IJERPH, MDPI, vol. 19(20), pages 1-4, October.

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