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Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients

Author

Listed:
  • Florent Besnier

    (Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
    Department of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada)

  • Béatrice Bérubé

    (Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
    Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada)

  • Christine Gagnon

    (Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
    Department of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada
    Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada)

  • Miloudza Olmand

    (Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
    Department of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada)

  • Paula Aver Bretanha Ribeiro

    (Research Centre, University of Montreal Hospital Research Centre, Montreal, QC H2X 0A9, Canada)

  • Anil Nigam

    (Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
    Department of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada)

  • Martin Juneau

    (Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
    Department of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada)

  • Lucie Blondeau

    (Montreal Health Innovations Coordinating Center, Montreal Heart Institute, Montreal, QC H1T 1C8, Canada)

  • Michel White

    (Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
    Department of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada)

  • Vincent Gremeaux

    (Sport Medicine Unit, Division of Physical Medicine and Rehabilitation, Swiss Olympic Medical Center, Lausanne University Hospital, 1011 Lausanne, Switzerland)

  • Louis Bherer

    (Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
    Department of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada
    Research Centre, Institut Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada)

  • Mathieu Gayda

    (Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
    Department of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada)

Abstract

We compared cognitive profiles in chronic heart failure patients (HF), heart transplant recipients (HT) and healthy controls (HC) and examined the relationship between cardiorespiratory fitness ( V ˙ O 2peak ), peak cardiac output (CO peak ) and cognitive performance. Stable HT patients ( n = 11), HF patients ( n = 11) and HC ( n = 13) (61.5 ± 8.5 years) were recruited. Four cognitive composite scores targeting different cognitive functions were computed from neuropsychological tests: working memory, processing speed, executive functions and verbal memory. Processing speed and executive function scores were higher, which indicates lower performances in HF and HT compared to HC ( p < 0.05). V ˙ O 2peak and first ventilatory threshold (VT 1 ) were lower in HF and HT vs. HC ( p < 0.01). CO peak was lower in HF vs. HT and HC ( p < 0.01). Processing speed, executive function and verbal memory performances were correlated with V ˙ O 2peak , VT 1 and peak cardiac hemodynamics ( p < 0.05). Mediation analyses showed that V ˙ O 2peak and VT 1 mediated the relationship between group and processing speed and executive function performances in HF and HT. CO peak fully mediated executive function and processing speed performances in HF only. V ˙ O 2peak and CO peak were related to cognitive performance in the entire sample. In addition, V ˙ O 2peak and VT 1 fully mediated the relationship between group and executive function and processing speed performances.

Suggested Citation

  • Florent Besnier & Béatrice Bérubé & Christine Gagnon & Miloudza Olmand & Paula Aver Bretanha Ribeiro & Anil Nigam & Martin Juneau & Lucie Blondeau & Michel White & Vincent Gremeaux & Louis Bherer & Ma, 2020. "Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients," IJERPH, MDPI, vol. 17(22), pages 1-14, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:22:p:8591-:d:447570
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    References listed on IDEAS

    as
    1. Jong Kyung Lee & Youn-Jung Son, 2018. "Gender Differences in the Impact of Cognitive Function on Health Literacy among Older Adults with Heart Failure," IJERPH, MDPI, vol. 15(12), pages 1-11, December.
    2. Laurence Desjardins-Crépeau & Nicolas Berryman & Thien Tuong Minh Vu & Juan Manuel Villalpando & Marie-Jeanne Kergoat & Karen Z. Li & Laurent Bosquet & Louis Bherer, 2014. "Physical Functioning Is Associated With Processing Speed and Executive Functions in Community-Dwelling Older Adults," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 69(6), pages 837-844.
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    Cited by:

    1. Florent Besnier & Christine Gagnon & Meghann Monnet & Olivier Dupuy & Anil Nigam & Martin Juneau & Louis Bherer & Mathieu Gayda, 2023. "Acute Effects of a Maximal Cardiopulmonary Exercise Test on Cardiac Hemodynamic and Cerebrovascular Response and Their Relationship with Cognitive Performance in Individuals with Type 2 Diabetes," IJERPH, MDPI, vol. 20(8), pages 1-14, April.

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