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Particulate Matter (PM 2.5 ) from Biomass Combustion Induces an Anti-Oxidative Response and Cancer Drug Resistance in Human Bronchial Epithelial BEAS-2B Cells

Author

Listed:
  • Regina Merk

    (Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, Albert Ludwigs University Freiburg, 79104 Freiburg, Germany
    Formerly Dornhof.)

  • Katharina Heßelbach

    (Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, Albert Ludwigs University Freiburg, 79104 Freiburg, Germany)

  • Anastasiya Osipova

    (Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, Albert Ludwigs University Freiburg, 79104 Freiburg, Germany)

  • Désirée Popadić

    (Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, Albert Ludwigs University Freiburg, 79104 Freiburg, Germany)

  • Wolfgang Schmidt-Heck

    (Department of Systems Biology and Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll Institute (HKI), 07745 Jena, Germany)

  • Gwang-Jin Kim

    (Department of Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences, Albert-Ludwigs University Freiburg, 79104 Freiburg, Germany)

  • Stefan Günther

    (Department of Pharmaceutical Bioinformatics, Institute of Pharmaceutical Sciences, Albert-Ludwigs University Freiburg, 79104 Freiburg, Germany)

  • Alfonso García Piñeres

    (Centro de Investigación en Biología Celular y Molecular (CIBCM), Universidad de Costa Rica, 11501-2060 San José, Costa Rica
    Escuela de Química, Universidad de Costa Rica, 11501-2060 San José, Costa Rica)

  • Irmgard Merfort

    (Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, Albert Ludwigs University Freiburg, 79104 Freiburg, Germany
    Spemann Graduate School of Biology and Medicine (SGBM), Albert-Ludwigs University Freiburg, 79104 Freiburg, Germany
    Authors contributed equally to this work.)

  • Matjaz Humar

    (Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, Albert Ludwigs University Freiburg, 79104 Freiburg, Germany
    Authors contributed equally to this work.)

Abstract

Nearly half of the world’s population relies on combustion of solid biofuels to cover fundamental energy demands. Epidemiologic data demonstrate that particularly long-term emissions adversely affect human health. However, pathological molecular mechanisms are insufficiently characterized. Here we demonstrate that long-term exposure to fine particulate matter (PM 2.5 ) from biomass combustion had no impact on cellular viability and proliferation but increased intracellular reactive oxygen species (ROS) levels in bronchial epithelial BEAS-2B cells. Exposure to PM 2.5 induced the nuclear factor erythroid 2-related factor 2 (Nrf2) and mediated an anti-oxidative response, including enhanced levels of intracellular glutathione (GSH) and nuclear accumulation of heme oxygenase-1 (HO-1). Activation of Nrf2 was promoted by the c-Jun N-terminal kinase JNK1/2, but not p38 or Akt, which were also induced by PM 2.5 . Furthermore, cells exposed to PM 2.5 acquired chemoresistance to doxorubicin, which was associated with inhibition of apoptosis and elevated levels of GSH in these cells. Our findings propose that exposure to PM 2.5 induces molecular defense mechanisms, which prevent cellular damage and may thus explain the initially relative rare complications associated with PM 2.5 . However, consistent induction of pro-survival pathways may also promote the progression of diseases. Environmental conditions inducing anti-oxidative responses may have the potential to promote a chemoresistant cellular phenotype.

Suggested Citation

  • Regina Merk & Katharina Heßelbach & Anastasiya Osipova & Désirée Popadić & Wolfgang Schmidt-Heck & Gwang-Jin Kim & Stefan Günther & Alfonso García Piñeres & Irmgard Merfort & Matjaz Humar, 2020. "Particulate Matter (PM 2.5 ) from Biomass Combustion Induces an Anti-Oxidative Response and Cancer Drug Resistance in Human Bronchial Epithelial BEAS-2B Cells," IJERPH, MDPI, vol. 17(21), pages 1-22, November.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:8193-:d:440765
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    References listed on IDEAS

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    1. Judy Y. Ou & Heidi A. Hanson & Joemy M. Ramsay & Claire L. Leiser & Yue Zhang & James A. VanDerslice & C. Arden Pope & Anne C. Kirchhoff, 2019. "Fine Particulate Matter and Respiratory Healthcare Encounters among Survivors of Childhood Cancers," IJERPH, MDPI, vol. 16(6), pages 1-16, March.
    2. Krassi Rumchev & Yun Zhao & Jeffery Spickett, 2017. "Health Risk Assessment of Indoor Air Quality, Socioeconomic and House Characteristics on Respiratory Health among Women and Children of Tirupur, South India," IJERPH, MDPI, vol. 14(4), pages 1-12, April.
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    Cited by:

    1. Francisco Alejandro Lagunas-Rangel & Wen Liu & Helgi B. Schiöth, 2022. "Can Exposure to Environmental Pollutants Be Associated with Less Effective Chemotherapy in Cancer Patients?," IJERPH, MDPI, vol. 19(4), pages 1-16, February.

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