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Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study

Author

Listed:
  • Hanna B Åhman

    (Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden)

  • Lars Berglund

    (Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden
    School of Education, Health and Social Studies, Dalarna University, SE-791 88 Falun, Sweden)

  • Ylva Cedervall

    (Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden)

  • Lena Kilander

    (Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden)

  • Vilmantas Giedraitis

    (Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden)

  • Kevin J. McKee

    (School of Education, Health and Social Studies, Dalarna University, SE-791 88 Falun, Sweden)

  • Martin Ingelsson

    (Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden)

  • Erik Rosendahl

    (Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, SE-901 87 Umeå, Sweden)

  • Anna Cristina Åberg

    (Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, SE-751 22 Uppsala, Sweden
    School of Education, Health and Social Studies, Dalarna University, SE-791 88 Falun, Sweden)

Abstract

The aim of this study was to investigate whether Timed Up-and-Go (TUG) dual-task (TUGdt) tests predict dementia incidence among patients with subjective or mild cognitive impairment (SCI; MCI). Other study objectives were to determine whether TUGdt improves dementia prediction compared to a) demographic characteristics and standard cognitive tests alone; and b) TUG and Verbal Fluency performed separately. Patients ( n = 172, age range 39–91 years, 78 women) with SCI or MCI performed TUGdt tests, including 1) naming animals and 2) reciting months backwards, and clinical cognitive tests at baseline. Diagnoses were identified at follow-up after 2.5 years. Logistic regression was used to predict dementia incidence, receiver operating characteristic (ROC) curves and c-statistics for predictive capacity. Analyses were stratified by age and gender. At follow-up, 51 patients had developed dementia. The TUGdt result “animals/10 s” was associated with dementia incidence (standardized odds ratio (OR) = 4.06, 95% confidence interval (CI) 2.28–7.23, p < 0.001), more so among patients under the median age of 72 years (standardized OR = 19.4, 95% CI 3.53–106.17, p < 0.001). TUGdt “animals/10 s” improved dementia prediction compared to demographic characteristics and standard tests alone (c-statistics 0.88 to 0.94) and single-task tests (c-statistics 0.86 to 0.89), but only in the younger patient group. TUGdt has the potential to become a useful tool for dementia prediction.

Suggested Citation

  • Hanna B Åhman & Lars Berglund & Ylva Cedervall & Lena Kilander & Vilmantas Giedraitis & Kevin J. McKee & Martin Ingelsson & Erik Rosendahl & Anna Cristina Åberg, 2020. "Dual-Task Tests Predict Conversion to Dementia—A Prospective Memory-Clinic-Based Cohort Study," IJERPH, MDPI, vol. 17(21), pages 1-14, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:8129-:d:439569
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    References listed on IDEAS

    as
    1. Ylva Cedervall & Anna M. Stenberg & Hanna B. Åhman & Vilmantas Giedraitis & Fredrik Tinmark & Lars Berglund & Kjartan Halvorsen & Martin Ingelsson & Erik Rosendahl & Anna Cristina Åberg, 2020. "Timed Up-and-Go Dual-Task Testing in the Assessment of Cognitive Function: A Mixed Methods Observational Study for Development of the UDDGait Protocol," IJERPH, MDPI, vol. 17(5), pages 1-19, March.
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