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PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Author

Listed:
  • Marco Bonato

    (Department of Biology, University of Padova, 35131 Padova, Italy
    These authors contributed equally as first authors.)

  • Francesca Corrà

    (Department of Biology, University of Padova, 35131 Padova, Italy
    These authors contributed equally as first authors.)

  • Marta Bellio

    (Department of Biology, University of Padova, 35131 Padova, Italy)

  • Laura Guidolin

    (Department of Biology, University of Padova, 35131 Padova, Italy)

  • Laura Tallandini

    (Department of Biology, University of Padova, 35131 Padova, Italy
    These authors contributed equally as first authors.)

  • Paola Irato

    (Department of Biology, University of Padova, 35131 Padova, Italy)

  • Gianfranco Santovito

    (Department of Biology, University of Padova, 35131 Padova, Italy)

Abstract

Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in the Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders, and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

Suggested Citation

  • Marco Bonato & Francesca Corrà & Marta Bellio & Laura Guidolin & Laura Tallandini & Paola Irato & Gianfranco Santovito, 2020. "PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field," IJERPH, MDPI, vol. 17(21), pages 1-45, October.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:8020-:d:437948
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    References listed on IDEAS

    as
    1. Meng-Shan Tsai & Chihiro Miyashita & Atsuko Araki & Sachiko Itoh & Yu Ait Bamai & Houman Goudarzi & Emiko Okada & Ikuko Kashino & Hideyuki Matsuura & Reiko Kishi, 2018. "Determinants and Temporal Trends of Perfluoroalkyl Substances in Pregnant Women: The Hokkaido Study on Environment and Children’s Health," IJERPH, MDPI, vol. 15(5), pages 1-14, May.
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    Cited by:

    1. Marialuisa Menegatto & Sara Lezzi & Michele Musolino & Adriano Zamperini, 2022. "The Psychological Impact of Per- and Poly-Fluoroalkyl Substances (PFAS) Pollution in the Veneto Region, Italy: A Qualitative Study with Parents," IJERPH, MDPI, vol. 19(22), pages 1-22, November.

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