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Serum Calprotectin and Chemerin Concentrations as Markers of Low-Grade Inflammation in Prepubertal Children with Obesity

Author

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  • Grażyna Rowicka

    (Department of Nutrition, Institute of Mother and Child, 01-211 Warsaw, Poland)

  • Hanna Dyląg

    (Department of Nutrition, Institute of Mother and Child, 01-211 Warsaw, Poland)

  • Magdalena Chełchowska

    (Department of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland)

  • Halina Weker

    (Department of Nutrition, Institute of Mother and Child, 01-211 Warsaw, Poland)

  • Jadwiga Ambroszkiewicz

    (Department of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland)

Abstract

In adults, obesity is associated with chronic low-grade inflammation, which may cause long-term adverse health consequences. We evaluated whether obesity in prepubertal children also generates this kind of inflammation and whether calprotectin and chemerin may be useful markers for early detection of such inflammation in this group of children. The study population included 83 children aged 2 to 10 years; 62 with obesity and without components of metabolic syndrome and 21 healthy controls with normal body weight. White blood cell (WBC) count, concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), calprotectin, and chemerin were determined in peripheral blood. Our study showed that in the group with obesity, serum concentrations of calprotectin and chemerin, as well as CRP were significantly higher as compared with the controls. We found a significant positive correlation between serum chemerin concentrations and BMI z-score (r = 0.33, p < 0.01) in children with obesity. Chemerin concentration was also positively correlated with CRP level (r = 0.36, p < 0.01) in the whole group of children. These findings suggest that obesity may generate chronic low-grade inflammation as early as in the prepubertal period which can be indicated by significantly higher serum concentrations of calprotectin and chemerin. Calprotectin and especially chemerin seem to be promising indicators of this type of inflammation in children with obesity, but the correlation between these markers requires further research.

Suggested Citation

  • Grażyna Rowicka & Hanna Dyląg & Magdalena Chełchowska & Halina Weker & Jadwiga Ambroszkiewicz, 2020. "Serum Calprotectin and Chemerin Concentrations as Markers of Low-Grade Inflammation in Prepubertal Children with Obesity," IJERPH, MDPI, vol. 17(20), pages 1-10, October.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:20:p:7575-:d:430823
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    References listed on IDEAS

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    1. Ya Li & Bingyin Shi & Sheli Li, 2014. "Association between Serum Chemerin Concentrations and Clinical Indices in Obesity or Metabolic Syndrome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-14, December.
    2. Joanna Szczyrska & Agnieszka Jankowska & Michał Brzeziński & Marek Jankowski & Paulina Metelska & Agnieszka Szlagatys-Sidorkiewicz, 2020. "Prevalence of Overweight and Obesity in 6–7-Year-Old Children—A Result of 9-Year Analysis of Big City Population in Poland," IJERPH, MDPI, vol. 17(10), pages 1-9, May.
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