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Medication Adherence, Burden and Health-Related Quality of Life in Adults with Predialysis Chronic Kidney Disease: A Prospective Cohort Study

Author

Listed:
  • Wubshet H. Tesfaye

    (Pharmacy, School of Medicine, College of Health and Medicine, University of Tasmania, Hobart 7005, Tasmania, Australia)

  • Charlotte McKercher

    (Menzies Institute for Medical Research, Hobart 7000, Tasmania, Australia)

  • Gregory M. Peterson

    (Pharmacy, School of Medicine, College of Health and Medicine, University of Tasmania, Hobart 7005, Tasmania, Australia)

  • Ronald L. Castelino

    (Sydney Nursing School, The University of Sydney, Sydney 2006, New South Wales, Australia)

  • Matthew Jose

    (Sydney Nursing School, The University of Sydney, Sydney 2006, New South Wales, Australia
    Royal Hobart Hospital, Hobart 7000, Tasmania, Australia)

  • Syed Tabish R. Zaidi

    (School of Healthcare, University of Leeds, Leeds LS2 9JT, UK)

  • Barbara C. Wimmer

    (Pharmacy, School of Medicine, College of Health and Medicine, University of Tasmania, Hobart 7005, Tasmania, Australia)

Abstract

This study examines the associations between medication adherence and burden, and health-related quality of life (HRQOL) in predialysis chronic kidney disease (CKD). A prospective study targeting adults with advanced CKD (estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m 2 ) and not receiving renal replacement therapy was conducted in Tasmania, Australia. The actual medication burden was assessed using the 65-item Medication Regimen Complexity Index, whereas perceived burden was self-reported using a brief validated questionnaire. Medication adherence was assessed using a four-item Morisky-Green-Levine Scale (MGLS) and the Tool for Adherence Behaviour Screening (TABS). The Kidney Disease and Quality of Life Short-Form was used to assess HRQOL. Of 464 eligible adults, 101 participated in the baseline interview and 63 completed a follow-up interview at around 14 months. Participants were predominantly men (67%), with a mean age of 72 (SD 11) years and eGFR of 21 (SD 6) mL/min/1.73 m 2 . Overall, 43% and 60% of participants reported medication nonadherence based on MGLS and TABS, respectively. Higher perceived medication burden and desire for decision-making were associated with nonadherent behaviour. Poorer HRQOL was associated with higher regimen complexity, whereas nonadherence was associated with a decline in physical HRQOL over time. Medication nonadherence, driven by perceived medication burden, was prevalent in this cohort, and was associated with a decline in physical HRQOL over time.

Suggested Citation

  • Wubshet H. Tesfaye & Charlotte McKercher & Gregory M. Peterson & Ronald L. Castelino & Matthew Jose & Syed Tabish R. Zaidi & Barbara C. Wimmer, 2020. "Medication Adherence, Burden and Health-Related Quality of Life in Adults with Predialysis Chronic Kidney Disease: A Prospective Cohort Study," IJERPH, MDPI, vol. 17(1), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:1:p:371-:d:305609
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    Citations

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    Cited by:

    1. Ibrahim Sales & Ghada Bawazeer & Ahmad R. Tarakji & Feriel K. Ben Salha & Nourah H. Al-Deaiji & Marwah Saeed & Rawan S. Idris & Mohammad H. Aljawadi & Majidah A. Aljohani & Mansour Adam Mahmoud & Waji, 2021. "Assessment of Dietary Folate Intake and Pill Burden among Saudi Patients on Maintenance Hemodialysis," IJERPH, MDPI, vol. 18(23), pages 1-10, December.
    2. Muhammad Daoud Butt & Siew Chin Ong & Fatima Zahid Butt & Ahsan Sajjad & Muhammad Fawad Rasool & Imran Imran & Tanveer Ahmad & Faleh Alqahtani & Zaheer-Ud-Din Babar, 2022. "Assessment of Health-Related Quality of Life, Medication Adherence, and Prevalence of Depression in Kidney Failure Patients," IJERPH, MDPI, vol. 19(22), pages 1-16, November.

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