Challenges in Infection Epidemiology: On the Underreporting of Norovirus Gastroenteritis Cases in Germany

It is commonly accepted that the number of officially reported incidences of norovirus (NoV) according to the German Protection against Infection Act ( Infektionsschutzgesetz ) does not reflect the ‘true’ incidence of NoV in Germany. This study aims to reveal the reasons for the underreporting of NoV cases by comparing secondary data. Methods: NoV incidence (cases per 100,000 reference persons) in the age group 18–65 was derived from register data of four different sources in the German public health system (2011–2015): Statutory health insurance in the federal state of Lower Saxony (AOK; in- and outpatient cases), the Research Institute of Ambulatory Health Care in Germany (ZI; outpatient cases), the German Federal Statistical Office (inpatient cases; DESTATIS), and the Robert Koch Institute (RKI SurvStat; health reporting data). Results: the incidence derived from the AOK in Lower Saxony varied between 49 and 66 NoV cases per 100,000 persons and was thus lower than at the federal level. Incidences of all inpatient and outpatient data were lower than the incidence according to the RKI in the last 2–3 years of the observation period. Conclusions: the disagreement between NoV incidences calculated from secondary inpatient and outpatient data and the respective numbers published by the RKI can be regarded as an indication that not all NoV cases were reported to public health authorities. This might be due to missed cases during the notification procedure or misclassification of gastroenteritis cases by general practitioners. Considering the limitations associated with analyzing secondary data, the appropriateness of these assumptions should be verified in future studies.