IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i19p7136-d421471.html
   My bibliography  Save this article

Radiation Exposure Predicts Reported Vaccine Adverse Effects in Veterans with Gulf War Illness

Author

Listed:
  • Beatrice A. Golomb

    (Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093-0995, USA)

  • Emily Nguyen

    (Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093-0995, USA)

  • Eero Dinkeloo

    (Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093-0995, USA)

Abstract

Most people have no problems when administered vaccines; however, as with all drugs, reported adverse effects (rAEs) do occur. There is a need to better understand the potential predictors of reported vaccine AEs (rVaxAEs), including modifiable (environmental) predictors. Gulf War Veterans (GWV) who have Gulf War illness (GWI) report increased experiences of drug and chemical rAEs, extending to rVaxAEs. GWV provide an opportunity to examine the relationship between their reported exposures and rAEs. Forty one GWV with GWI and 40 healthy controls reported exposure and rAEs to exposure, including for 14 vaccines. Individual and summed vaccine exposures, rVaxAEs, and reported Vaccine AE Propensity (summed rVaxAEs/summed vaccines exposures) were compared in cases vs. controls. Exposure–outcome assessments focused on GWV, using a multivariable regression with robust standard error. More designated vaccines were reported in cases than in controls: 9.0 (2.3) vs. 3.8 (2.3), p < 0.0001. The fraction of vaccines received that led to rAEs was ten-fold higher in cases: 0.24 (0.21), vs. 0.023 (0.081), p < 0.0001. Multivariable assessment confirmed that radiation and pesticides remained significant statistical predictors of reported Vaccine AE Propensity. Exposure tied to excess rVaxAEs in GWV may contribute to, or underlie, the reported link between rVaxAEs in GWV and later ill health.

Suggested Citation

  • Beatrice A. Golomb & Emily Nguyen & Eero Dinkeloo, 2020. "Radiation Exposure Predicts Reported Vaccine Adverse Effects in Veterans with Gulf War Illness," IJERPH, MDPI, vol. 17(19), pages 1-14, September.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:19:p:7136-:d:421471
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/19/7136/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/19/7136/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:19:p:7136-:d:421471. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.