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Separation and HPLC Characterization of Active Natural Steroids in a Standardized Extract from the Serratula coronata Herb with Antiseborrheic Dermatitis Activity

Author

Listed:
  • Marta Napierała

    (Laboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Street, 60-631 Poznan, Poland)

  • Joanna Nawrot

    (Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, 33 Mazowiecka Street, 60-623 Poznan, Poland)

  • Justyna Gornowicz-Porowska

    (Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, 33 Mazowiecka Street, 60-623 Poznan, Poland)

  • Ewa Florek

    (Laboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Street, 60-631 Poznan, Poland)

  • Arletta Moroch

    (Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, 33 Mazowiecka Street, 60-623 Poznan, Poland)

  • Zygmunt Adamski

    (Department of Dermatology, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-356 Poznan, Poland)

  • Anna Kroma

    (Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, 33 Mazowiecka Street, 60-623 Poznan, Poland)

  • Izabela Miechowicz

    (Department of Computer Science and Statistics, Poznan University of Medical Sciences, 79 Dabrowskiego Street, 60-529 Poznan, Poland)

  • Gerard Nowak

    (Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, 33 Mazowiecka Street, 60-623 Poznan, Poland)

Abstract

Phytoecdysteroids are natural compounds with therapeutic benefits in both humans and animals. The effectiveness of natural products with health potential is based on the activities and potencies of their active ingredients. In this study, dominant ecdysteroids—ajugasterone C, 20-hydroxyecdysone and polypodine B—from the Serratula coronata ( S. coronata ) herb were separated by column chromatography, identified by spectroscopic data and quantified by high-performance liquid chromatography with a diode array detector (HPLC-DAD). The obtained concentration of ecdysteroids (approximately 23%) in the S. coronatae herb extract enhances the possibility of their use in pharmaceutical and cosmetic products with high levels of phytoecdysteroids. Moreover, this study has shown a positive effect of ecdysteroids-containing cream on changes in quality of life and a beneficial effect in reducing the symptoms of seborrheic dermatitis. It has been demonstrated that the application of the cream with phytoecdysteroids resulted in a statistically significant alleviation of symptoms ( p < 0.05), especially in terms of itching, pain or burning sensations in the affected areas in comparison to previous symptoms.

Suggested Citation

  • Marta Napierała & Joanna Nawrot & Justyna Gornowicz-Porowska & Ewa Florek & Arletta Moroch & Zygmunt Adamski & Anna Kroma & Izabela Miechowicz & Gerard Nowak, 2020. "Separation and HPLC Characterization of Active Natural Steroids in a Standardized Extract from the Serratula coronata Herb with Antiseborrheic Dermatitis Activity," IJERPH, MDPI, vol. 17(18), pages 1-12, September.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:18:p:6453-:d:408997
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    Cited by:

    1. Renjun Mao & Zhenqing Bai & Jiawen Wu & Ruilian Han & Xuemin Zhang & Weiguo Chai & Zongsuo Liang, 2022. "Transcriptome and HPLC Analysis Reveal the Regulatory Mechanisms of Aurantio-Obtusin in Space Environment-Induced Senna obtusifolia Lines," IJERPH, MDPI, vol. 19(2), pages 1-17, January.

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