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Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats

Author

Listed:
  • Miguel Morales-Navas

    (Department of Psychology and Health Research Center, University of Almería, Ctra. Sacramento, s/n, 04120 Almería, Spain)

  • Sergio Castaño-Castaño

    (Department of Psychology and Health Research Center, University of Almería, Ctra. Sacramento, s/n, 04120 Almería, Spain
    Department of Health Sciences, Universidad Europea del Atlántico, Calle Isabel Torres, 21, 39011 Santander, Spain)

  • Cristian Pérez-Fernández

    (Department of Psychology and Health Research Center, University of Almería, Ctra. Sacramento, s/n, 04120 Almería, Spain)

  • Ainhoa Sánchez-Gil

    (Department of Psychology and Health Research Center, University of Almería, Ctra. Sacramento, s/n, 04120 Almería, Spain)

  • María Teresa Colomina

    (Department of Psychology and Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, C/Carretera de Valls, s/n, 43007 Tarragona, Spain)

  • Xavier Leinekugel

    (Institut de Neurobiologie de la Mediterranée (INMED), INSERM UMR1249, Aix-Marseille University, Parc Scientifique de Luminy BP.13, CEDEX 09, 13273 Marseille, France)

  • Fernando Sánchez-Santed

    (Department of Psychology and Health Research Center, University of Almería, Ctra. Sacramento, s/n, 04120 Almería, Spain)

Abstract

Background: In recent years, ultrasonic vocalizations (USV) in pups has become established as a good tool for evaluating behaviors related to communication deficits and emotional states observed in autism spectrum disorder (ASD). Prenatal valproic acid (VPA) exposure leads to impairments and social behavior deficits associated with autism, with the effects of VPA being considered as a reliable animal model of ASD. Some studies also suggest that prenatal exposure to chlorpyrifos (CPF) could enhance autistic-like behaviors. Methods: In order to explore these similarities, in the present study we tested whether prenatal exposure to CPF at GD12.5–14.5 produces effects that are comparable to those produced by prenatal VPA exposure at GD12.5 in infant Wistar rats. Using Deep Squeek software, we evaluated total number of USVs, latency to the first call, mean call duration, principal frequency peak, high frequency peak, and type of calls. Results: Consistent with our hypothesis, we found that exposure to both CPF and VPA leads to a significantly smaller number of calls along with a longer latency to produce the first call. No significant effects were found for the remaining dependent variables. Conclusions: These results suggest that prenatal exposure to CPF could produce certain behaviors that are reminiscent of those observed in ASD patients.

Suggested Citation

  • Miguel Morales-Navas & Sergio Castaño-Castaño & Cristian Pérez-Fernández & Ainhoa Sánchez-Gil & María Teresa Colomina & Xavier Leinekugel & Fernando Sánchez-Santed, 2020. "Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats," IJERPH, MDPI, vol. 17(17), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:17:p:6376-:d:407387
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    Cited by:

    1. Rayane M. Botelho & Ana Lúcia M. Silva & Alexandre U. Borbely, 2024. "The Autism Spectrum Disorder and Its Possible Origins in Pregnancy," IJERPH, MDPI, vol. 21(3), pages 1-22, February.

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