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Association of Liver Transaminase Levels and Long-Term Blood Pressure Variability in Military Young Males: The CHIEF Study

Author

Listed:
  • Pang-Yen Liu

    (Department of Cardiovascular Medicine, School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
    Department of Internal Medicine, Tri-Service General Hospital and National Defense Medical Center, Taipei 114, Taiwan)

  • Yu-Kai Lin

    (Department of Medicine, Hualien Armed Forces General Hospital, Hualien 971, Taiwan
    Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan)

  • Kai-Wen Chen

    (Department of Medicine, Hualien Armed Forces General Hospital, Hualien 971, Taiwan)

  • Kun-Zhe Tsai

    (Department of Medicine, Hualien Armed Forces General Hospital, Hualien 971, Taiwan)

  • Yen-Po Lin

    (Department of Critical Care Medicine, Taipei Tzu-Chi General Hospital, New Taipei City 231, Taiwan)

  • Eiki Takimoto

    (Department of Cardiovascular Medicine, School of Medicine, University of Tokyo, Tokyo 113-0033, Japan)

  • Gen-Min Lin

    (Department of Internal Medicine, Tri-Service General Hospital and National Defense Medical Center, Taipei 114, Taiwan
    Department of Medicine, Hualien Armed Forces General Hospital, Hualien 971, Taiwan
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA)

Abstract

Background : An inverse relationship of serum liver transaminases and mortality might be due to better blood pressure control in hypertensive patients. Whether it holds true regarding such an association for long-term blood pressure variability (BPV) in those without antihypertensive therapy is unclear. Methods : A population of 1112 military males without antihypertensive medications, aged 32 years, was collected from a retrospective longitudinal study in Taiwan. Serum liver aspartate and alanine transaminase (AST and ALT) levels were obtained from a 12 h-fast blood sample of each participant. BPV was assessed by standard deviation (SD) and average real variability (ARV) of systolic and diastolic blood pressure (SBP and DBP), respectively across 4 visits during the study period (2012–2014, 2014–2015, 2015–2016, and 2016–2018). Multivariable linear regression analysis was utilized to determine the association adjusting for demographics, anthropometric indexes, SBP, DBP, and lipid profiles. Results : In the unadjusted model, ALT was significantly and positively correlated with SD DBP and ARV DBP (β (standard errors) = 0.36 (0.16) and 0.24 (0.12), respectively), and so was AST (β = 0.19 (0.08) and 0.14 (0.06), respectively). All the associations were insignificant with adjustments. However, ALT was significantly and negatively correlated with SD SBP and ARV SBP (β = −0.35 (0.14) and −0.25 (0.11), respectively) and so was AST (β = −0.14 (0.07) and −0.12 (0.06), respectively) with adjustments. Conclusion : Our findings suggested that serum liver transaminases were negatively correlated with long-term systolic BPV in young male adults without antihypertensive therapy, and the clinical relevance needs further investigations.

Suggested Citation

  • Pang-Yen Liu & Yu-Kai Lin & Kai-Wen Chen & Kun-Zhe Tsai & Yen-Po Lin & Eiki Takimoto & Gen-Min Lin, 2020. "Association of Liver Transaminase Levels and Long-Term Blood Pressure Variability in Military Young Males: The CHIEF Study," IJERPH, MDPI, vol. 17(17), pages 1-10, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:17:p:6094-:d:402334
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    References listed on IDEAS

    as
    1. Kai-Wen Chen & Fan-Chun Meng & Yu-Lueng Shih & Fang-Ying Su & Yen-Po Lin & Felicia Lin & Jia-Wei Lin & Wei-Kuo Chang & Chung-Jen Lee & Yi-Hwei Li & Chung-Bao Hsieh & Gen-Min Lin, 2018. "Sex-Specific Association between Metabolic Abnormalities and Elevated Alanine Aminotransferase Levels in a Military Cohort: The CHIEF Study," IJERPH, MDPI, vol. 15(3), pages 1-10, March.
    2. Hae Ran Kim & Mi Ah Han, 2018. "Association between Serum Liver Enzymes and Metabolic Syndrome in Korean Adults," IJERPH, MDPI, vol. 15(8), pages 1-9, August.
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