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Risk of Mitral Valve Prolapse in Patients with Keratoconus in Taiwan: A Population-Based Cohort Study

Author

Listed:
  • Yuh-Shin Chang

    (Department of Ophthalmology, Chi Mei Medical Center, Tainan 710, Taiwan
    Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan)

  • Ming-Cheng Tai

    (Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan)

  • Shih-Feng Weng

    (Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

  • Jhi-Joung Wang

    (Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan)

  • Sung-Huei Tseng

    (Department of Ophthalmology, Chi Mei Medical Center, Tainan 710, Taiwan
    Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan)

  • Ren-Long Jan

    (Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan
    Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan)

Abstract

This retrospective, nationwide, matched-cohort study included 4488 new-onset keratoconus (KCN) patients, ≥12 years old, recruited between 2004 and 2011 from the Taiwan National Health Insurance Research Database. The control group included 26,928 non-KCN patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Information for each patient was collected and tracked from the index date until December 2013. The incidence rate of mitral valve prolapse (MVP) was 1.77 times (95% confidence interval (CI) = 1.09–2.88; p = 0.0206) higher in KCN patients ≥40 years old and 1.49 times (95% CI = 1.12–1.98; p = 0.0060) higher in female KCN patients than in controls. After using the Cox proportional hazard regression analysis to adjust for potential confounders, including hypertension, hyperlipidemia, and congestive heart failure, KCN maintained an independent risk factor, MVP being 1.77 times (adjusted hazard ratio (HR) = 1.77, 95% CI = 1.09–2.88) and 1.48 times (adjusted HR = 1.48, 95% CI = 1.11–1.97) more likely to develop in patients ≥40 years old and female patients in the study cohort, respectively. We found that KCN patients ≥40 years of age and female KCN patients have increased risks of MVP. Therefore, it is recommended that KCN patients should be alerted to MVP.

Suggested Citation

  • Yuh-Shin Chang & Ming-Cheng Tai & Shih-Feng Weng & Jhi-Joung Wang & Sung-Huei Tseng & Ren-Long Jan, 2020. "Risk of Mitral Valve Prolapse in Patients with Keratoconus in Taiwan: A Population-Based Cohort Study," IJERPH, MDPI, vol. 17(17), pages 1-10, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:17:p:6049-:d:401465
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