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Insights from Experiences on Antiplatelet Drugs in Stroke Prevention: A Review

Author

Listed:
  • Salvatore Santo Signorelli

    (Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy
    General Medicine Division, University Hospital G. Rodolico, 95123 Catania, Italy)

  • Ingrid Platania

    (General Medicine Division, University Hospital G. Rodolico, 95123 Catania, Italy)

  • Salvatore Davide Tomasello

    (Division of Hemodynamic and Interventional Cardiology, Hospital Cannizzaro, 95123 Catania, Italy)

  • Marco Mangiafico

    (Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

  • Giuliana Barcellona

    (Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy
    General Medicine Division, University Hospital G. Rodolico, 95123 Catania, Italy)

  • Domenico Di Raimondo

    (Division of Internal Medicine and Stroke Care, Department of Promoting Health, Maternal-Infant, Excellence and Internal and Specialized Medicine (Promise) G. D’Alessandro, University of Palermo, 90127 Palermo, Italy)

  • Agostino Gaudio

    (Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy)

Abstract

Reduction of hazard risk of cerebral ischemic event (stroke, transient ischemic attack (TIA)) represents the hard point to be achieved from primary or secondary preventive strategy in the best clinical practice. However, results from clinical trials, recommendations, guidelines, systematic review, expert opinions, and meta-analysis debated on the optimal pharmacotherapy to achieve the objective. Aspirin and a number of antiplatelet agents, alone or in combination, have been considered from large trials focused on stroke prevention. The present review summarizes, discusses results from trials, and focuses on the benefits or disadvantages originating from antiplatelet drugs. Sections of the review were organized to show both benefits or consequences from antiplatelet pharmacotherapy. Conclusively, this review provides a potential synopsis on the most appropriate therapeutic approach for stroke prevention in clinical practice.

Suggested Citation

  • Salvatore Santo Signorelli & Ingrid Platania & Salvatore Davide Tomasello & Marco Mangiafico & Giuliana Barcellona & Domenico Di Raimondo & Agostino Gaudio, 2020. "Insights from Experiences on Antiplatelet Drugs in Stroke Prevention: A Review," IJERPH, MDPI, vol. 17(16), pages 1-15, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:16:p:5840-:d:398121
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    Cited by:

    1. Domenico Di Raimondo & Gaia Musiari & Giuliana Rizzo & Edoardo Pirera & Salvatore Santo Signorelli, 2022. "New Insights in Prevention and Treatment of Cardiovascular Disease," IJERPH, MDPI, vol. 19(4), pages 1-7, February.

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