IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i16p5667-d395044.html
   My bibliography  Save this article

Voluntary Physical Exercise Reduces Motor Dysfunction and Hampers Tumor Cell Proliferation in a Mouse Model of Glioma

Author

Listed:
  • Elena Tantillo

    (Neuroscience Institute, National Research Council (CNR), 56124 Pisa, Italy
    Classe di Scienze, Scuola Normale Superiore, 56124 Pisa, Italy)

  • Antonella Colistra

    (Neuroscience Institute, National Research Council (CNR), 56124 Pisa, Italy)

  • Laura Baroncelli

    (Neuroscience Institute, National Research Council (CNR), 56124 Pisa, Italy
    IRCCS Fondazione Stella Maris, 56128 Calambrone, Italy)

  • Mario Costa

    (Neuroscience Institute, National Research Council (CNR), 56124 Pisa, Italy)

  • Matteo Caleo

    (Neuroscience Institute, National Research Council (CNR), 56124 Pisa, Italy
    Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy
    Matteo Caleo and Eleonora Vannini share equal contribution as senior authors.)

  • Eleonora Vannini

    (Neuroscience Institute, National Research Council (CNR), 56124 Pisa, Italy
    Fondazione Umberto Veronesi, 20122 Milan, Italy
    Matteo Caleo and Eleonora Vannini share equal contribution as senior authors.)

Abstract

Currently, high-grade gliomas are the most difficult brain cancers to treat and all the approved experimental treatments do not offer long-term benefits regarding symptom improvement. Epidemiological studies indicate that exercise decreases the risk of brain cancer mortality, but a direct relationship between physical exercise and glioma progression has not been established so far. Here, we exploited a mouse model of high-grade glioma to directly test the impact of voluntary physical exercise on the tumor proliferation and motor capabilities of affected animals. We report that exposing symptomatic, glioma-bearing mice to running wheels (i) reduced the proliferation rate of tumors implanted in the motor cortex and (ii) delayed glioma-induced motor dysfunction. Thus, voluntary physical exercise might represent a supportive intervention that complements existing neuro-oncologic therapies, contributing to the preservation of functional motor ability and counteracting the detrimental effects of glioma on behavioral output.

Suggested Citation

  • Elena Tantillo & Antonella Colistra & Laura Baroncelli & Mario Costa & Matteo Caleo & Eleonora Vannini, 2020. "Voluntary Physical Exercise Reduces Motor Dysfunction and Hampers Tumor Cell Proliferation in a Mouse Model of Glioma," IJERPH, MDPI, vol. 17(16), pages 1-12, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:16:p:5667-:d:395044
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/16/5667/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/16/5667/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:16:p:5667-:d:395044. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.