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Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study

Author

Listed:
  • Yolanda Benavente

    (Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
    Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    These authors contributed equally to this article.)

  • Laura Costas

    (Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
    These authors contributed equally to this article.)

  • Marta Maria Rodríguez-Suarez

    (Public Health Department, University of Oviedo, 33011 Oviedo, Spain
    Occupational Risk Prevention Service, Hospital Central University of Asturias, Public Health Service of the Principado of Asturias (SESPA), 33006 Oviedo, Spain
    These authors contributed equally to this article.)

  • Juan Alguacil

    (Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, 21071 Huelva, Spain)

  • Miguel Santibáñez

    (Faculty of Nursing, University of Cantabria—IDIVAL, 39008 Santander, Spain)

  • Javier Vila

    (Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    ISGlobal, 08903 Barcelona, Spain
    Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain)

  • Claudia Robles

    (Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain)

  • Esther Alonso

    (Department of Pathology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08908 Barcelona, Spain)

  • Esmeralda de la Banda

    (Department of Pathology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, 08908 Barcelona, Spain)

  • Eva Gonzalez-Barca

    (Hematology, Institut Català d’ Oncologia (IDIBELL), Universitat de Barcelona, L’ Hospitalet de Llobregat, 08908 Barcelona, Spain)

  • Trinidad Dierssen-Sotos

    (Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    Faculty of Medicine, University of Cantabria—IDIVAL, 39011 Santander, Spain)

  • Eva Gimeno Vazquez

    (Hematology, Hospital del Mar, 08003 Barcelona, Spain)

  • Marta Aymerich

    (Hematopathology Unit/Hemato-Oncology Department, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), 08001 Barcelona, Spain
    Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28001 Madrid, Spain)

  • Elias Campo

    (Hematopathology Unit/Hemato-Oncology Department, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), 08001 Barcelona, Spain
    Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28001 Madrid, Spain)

  • José J. Jiménez-Moleón

    (Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    Department of Preventive Medicine and Public Health, University of Granada, 18071 Granada, Spain
    Instituto de Investigación Biosanitaria de Granada, Servicio Andaluz de Salud, Universidad de Granada, 18012 Granada, Spain)

  • Rafael Marcos-Gragera

    (Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), 17007 Girona, Spain)

  • Gemma Castaño-Vinyals

    (Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    ISGlobal, 08903 Barcelona, Spain
    Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain
    Hospital del Mar Medical Research Institute (IMIM), 08001 Barcelona, Spain)

  • Nuria Aragonés

    (Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    Department of Health of Madrid, Epidemiology Section, Public Health Division, 28035 Madrid, Spain)

  • Marina Pollan

    (Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    National Center for Epidemiology, Carlos III Institute of Health, 28001 Madrid, Spain
    Instituto de Investigación Sanitaria (IIS) de Hierro, 28220 Majadahonda, Spain)

  • Silvia de Sanjose

    (Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
    Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    Sexual and Reproductive Health, PATH, Seattle, WA 98121, USA)

  • Manolis Kogevinas

    (Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    ISGlobal, 08903 Barcelona, Spain
    Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain
    Hospital del Mar Medical Research Institute (IMIM), 08001 Barcelona, Spain)

  • Adonina Tardón

    (Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    IUOPA Medicine Department, University of Oviedo, 33003 Oviedo, Spain
    Institute of Health Research of the Principality of Asturias-Foundation for Biosanitary Research of Asturias (ISPA-FINBA), 33003 Oviedo, Spain
    These authors contributed equally to this article.)

  • Delphine Casabonne

    (Cancer Epidemiology Research Programme, Institut Català d’Oncologia (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
    Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), 28001 Madrid, Spain
    These authors contributed equally to this article.)

Abstract

We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain, 2010–2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs the product of prevalence, intensity and duration of exposure to each active substance. Principal components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend; 2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA, the first component (PC1, explaining 70% of the variation) equally led by seven active substances (the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm previous associations between CLL and exposure to pesticides and provide additional evidence by application groups and active substance. However, more research is needed to disentangle independent effects of individual active substances.

Suggested Citation

  • Yolanda Benavente & Laura Costas & Marta Maria Rodríguez-Suarez & Juan Alguacil & Miguel Santibáñez & Javier Vila & Claudia Robles & Esther Alonso & Esmeralda de la Banda & Eva Gonzalez-Barca & Trinid, 2020. "Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study," IJERPH, MDPI, vol. 17(14), pages 1-11, July.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:14:p:5174-:d:386148
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