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Analyzing the Association between Hyperuricemia and Periodontitis: A Cross-Sectional Study Using KoGES HEXA Data

Author

Listed:
  • Soo-Hwan Byun

    (Department of Oral & Maxillofacial Surgery, Dentistry, Hallym University College of Medicine, Anyang 14068, Korea
    Institute of Clinical Dentistry, Hallym University, Chuncheon 24252, Korea)

  • Dae-Myoung Yoo

    (Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea)

  • Jung-Woo Lee

    (Department of Orthopedic Surgery, Hallym University College of Medicine, Anyang 14068, Korea)

  • Hyo-Geun Choi

    (Institute of Clinical Dentistry, Hallym University, Chuncheon 24252, Korea
    Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
    Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Dongtan 14068, Korea)

Abstract

Hyperuricemia arises from the buildup of excessive uric acid in the blood, and it is implicated in the development of periodontitis. The objective of this study was to investigate the association between hyperuricemia and periodontitis using a cross-sectional study design and Korean Genome and Epidemiology Study Health Examinee (KoGES HEXA) data. This prospective cohort study used epidemiological data from the KoGES from 2004 to 2016. Among 173,209 participants, 8809 with hyperuricemia and 126,465 controls (non-hyperuricemia) were selected. This study defined hyperuricemia as >7.0 mg/dL of uric acid in men and >6.0 mg/dL in women. This study analyzed the history of periodontitis among hyperuricemia and control participants. Participants’ age, gender, income, obesity, smoking, alcohol consumption, and nutritional intake were all examined. Chi-square tests, independent t -tests, and two-tailed analyses were used for statistical analysis. The adjusted OR (aOR) of hyperuricemia for periodontitis was 0.89 (95% confidence interval (CI) = 0.81–0.96, p = 0.005). This study demonstrated that hyperuricemia was associated with periodontitis. This finding meant that elevated uric acid levels could have a positive effect on periodontitis. However, further studies should be performed to determine the range of uric acid levels beneficial to periodontal health.

Suggested Citation

  • Soo-Hwan Byun & Dae-Myoung Yoo & Jung-Woo Lee & Hyo-Geun Choi, 2020. "Analyzing the Association between Hyperuricemia and Periodontitis: A Cross-Sectional Study Using KoGES HEXA Data," IJERPH, MDPI, vol. 17(13), pages 1-10, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:13:p:4777-:d:379637
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