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Bone Metabolism in Patients Treated for Depression

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  • Elżbieta Skowrońska-Jóźwiak

    (Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland
    Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital—Research Institute, 93-338 Lodz, Poland)

  • Piotr Gałecki

    (Department of Adult Psychiatry, Medical University of Lodz, 91-229 Lodz, Poland)

  • Ewa Głowacka

    (Department of Laboratory Diagnostics, Polish Mother’s Memorial Hospital—Research Institute, 93-338 Lodz, Poland)

  • Cezary Wojtyła

    (Department of Oncological Gynecology and Obstetrics, Center of Postgraduate Medical Education, 00-416 Warsaw, Poland
    International Prevention Research Institute—Collaborating Centre, State University of Applied Sciences, 62-800 Kalisz, Poland)

  • Przemysław Biliński

    (Faculty of Heath Sciences, State University of Applied Sciences, 62-800 Kalisz, Poland
    Copernicus Memorial Comprehensive Cancer Center and Traumatology, 93-513 Lodz, Poland)

  • Andrzej Lewiński

    (Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland
    Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital—Research Institute, 93-338 Lodz, Poland)

Abstract

Background: Depression and osteoporosis are severe public health problems. There are conflicting findings regarding the influence of depression on bone metabolism. The aim of the presented study was to compare bone turnover markers and vitamin D levels between patients treated for depression and healthy controls. Patients and Methods: We determined a concentration of osteocalcin, carboxy-terminal telopeptide of type I collagen (β-CTX), 25-hydroxyvitamin D (25OHD) and 1,25(OH) 2 D 3 in 99 patients, aged 46.9 ± 11 years, treated for depression, as well as in 45 healthy subjects. Depressive status was determined with the Hamilton Depression Scale (HDRS). Results: In patients treated for depression, we demonstrated significantly lower osteocalcin concentrations ( p < 0.03) and higher concentration of β-CTX (result on the border of significance; p = 0.08). Those relationship were stronger in women. The level of 25OHD and 1,25(OH) 2 D 3 did not differ significantly between the examined groups. We observed a negative correlation between the 25OHD and HDRS score after treatment in all patients treated for depression and in subgroups of women and subjects with recurrent depression. Conclusions: Our results indicate that depression is related to disturbances in bone metabolism, especially in women and patients with recurrent depression, suggesting its role in context of osteoporosis development.

Suggested Citation

  • Elżbieta Skowrońska-Jóźwiak & Piotr Gałecki & Ewa Głowacka & Cezary Wojtyła & Przemysław Biliński & Andrzej Lewiński, 2020. "Bone Metabolism in Patients Treated for Depression," IJERPH, MDPI, vol. 17(13), pages 1-8, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:13:p:4756-:d:379332
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    References listed on IDEAS

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    1. Julietta Ursula Schweiger & Ulrich Schweiger & Michael Hüppe & Kai G. Kahl & Wiebke Greggersen & Kamila Jauch-Chara & Eva Fassbinder, 2018. "The Use of Antidepressive Agents and Bone Mineral Density in Women: A Meta-Analysis," IJERPH, MDPI, vol. 15(7), pages 1-11, June.
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