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The Association between Ethanol Elimination Rate and Hangover Severity

Author

Listed:
  • Marlou Mackus

    (Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584CG Utrecht, The Netherlands)

  • Aurora JAE van de Loo

    (Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584CG Utrecht, The Netherlands
    Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3584CM Utrecht, The Netherlands)

  • Johan Garssen

    (Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584CG Utrecht, The Netherlands
    Global Centre of Excellence Immunology, Nutricia Danone Research, 3584CT Utrecht, The Netherlands)

  • Aletta D Kraneveld

    (Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584CG Utrecht, The Netherlands)

  • Andrew Scholey

    (Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia)

  • Joris C Verster

    (Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584CG Utrecht, The Netherlands
    Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3584CM Utrecht, The Netherlands
    Centre for Human Psychopharmacology, Swinburne University, Melbourne VIC 3122, Australia)

Abstract

Assessments in blood and saliva suggests that the amount of ethanol present in the first hours after alcohol consumption and into the following morning is associated with hangover severity. The current analysis determines how ethanol elimination rate is related to hangover severity reported throughout the day. n = 8 subjects participated in two studies. The first was a naturalistic study comprising an evening of alcohol consumption. Hangover severity was assessed hourly from 10 a.m. to 4 p.m., using a 1-item hangover severity scale ranging from 0 (absent) to 10 (extreme). The second study comprised a highly controlled alcohol challenge to reach a breath alcohol concentration (BrAC) of 0.05%. Breathalyzer tests were conducted every 5 min until BrAC reached zero. The ethanol elimination rate, expressed in BrAC%/hour, was computed by dividing the peak BrAC (%) by the time to BrAC of zero (h). At 11:00, 13:00, and 14:00, there were significant negative partial correlations, controlling for estimated BrAC, between ethanol elimination rate and hangover severity. The findings suggest that drinkers with a faster ethanol elimination rate experience less severe hangovers. The observations should be confirmed in a larger sample of subjects who participate in a single study that assesses both hangover severity and ethanol elimination rate.

Suggested Citation

  • Marlou Mackus & Aurora JAE van de Loo & Johan Garssen & Aletta D Kraneveld & Andrew Scholey & Joris C Verster, 2020. "The Association between Ethanol Elimination Rate and Hangover Severity," IJERPH, MDPI, vol. 17(12), pages 1-9, June.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:12:p:4324-:d:372577
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    References listed on IDEAS

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    1. Aurora J. A. E. Van de Loo & Marlou Mackus & Marith Van Schrojenstein Lantman & Aletta D. Kraneveld & Karel A. Brookhuis & Johan Garssen & Andrew Scholey & Joris C. Verster, 2018. "Susceptibility to Alcohol Hangovers: The Association with Self-Reported Immune Status," IJERPH, MDPI, vol. 15(6), pages 1-8, June.
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    Cited by:

    1. Agnese Merlo & Noortje R Severeijns & Pauline A Hendriksen & Sarah Benson & Andrew Scholey & Johan Garssen & Gillian Bruce & Joris C Verster, 2022. "Alcohol Consumption on the Heaviest Drinking Occasion and Hangovers during the First Dutch COVID-19 Lockdown," IJERPH, MDPI, vol. 19(7), pages 1-12, April.

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