IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i11p4074-d368509.html
   My bibliography  Save this article

The Effects of 1-Hz rTMS on Emotional Behavior and Dendritic Complexity of Mature and Newly Generated Dentate Gyrus Neurons in Male Mice

Author

Listed:
  • Marco Cambiaghi

    (Department of Neurosciences, Biomedicine and Movement Sciences-University of Verona, 37134 Verona, Italy
    These authors contributed equally to this manuscript.)

  • Rosalia Crupi

    (Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98125 Messina, Italy
    These authors contributed equally to this manuscript.)

  • Erick Larios Bautista

    (Department of Medical Sciences, Neurology and Psychiatry, Hackensack Meridian School of Medicine, Seton Hall University, Nutley, NJ 07110, USA)

  • Amir Elsamadisi

    (Department of Medical Sciences, Neurology and Psychiatry, Hackensack Meridian School of Medicine, Seton Hall University, Nutley, NJ 07110, USA)

  • Wasib Malik

    (Department of Medical Sciences, Neurology and Psychiatry, Hackensack Meridian School of Medicine, Seton Hall University, Nutley, NJ 07110, USA)

  • Helen Pozdniakova

    (Department of Medical Sciences, Neurology and Psychiatry, Hackensack Meridian School of Medicine, Seton Hall University, Nutley, NJ 07110, USA)

  • Zhiyong Han

    (Department of Medical Sciences, Neurology and Psychiatry, Hackensack Meridian School of Medicine, Seton Hall University, Nutley, NJ 07110, USA)

  • Mario Buffelli

    (Department of Neurosciences, Biomedicine and Movement Sciences-University of Verona, 37134 Verona, Italy)

  • Fortunato Battaglia

    (Department of Medical Sciences, Neurology and Psychiatry, Hackensack Meridian School of Medicine, Seton Hall University, Nutley, NJ 07110, USA)

Abstract

Low-frequency repetitive transcranial magnetic stimulation (1-Hz rTMS) is a promising noninvasive tool for the treatment of depression. Hippocampal neuronal plasticity is thought to play a pivotal role in the pathophysiology of depressive disorders and the mechanism of action of antidepressant treatments. We investigated the effect of 1-Hz rTMS treatment on hippocampal dentate gyrus structural plasticity and related emotional behaviors modifications. Experimentally, adult male mice received either five days of 1-Hz rTMS or Sham stimulation. After stimulation, the mice underwent a battery of tests for anxiety-like and depression-like behaviors. We also tested the effect of treatment on mature and newly generated granule cell dendritic complexity. Our data showed that 1-Hz rTMS induced structural plasticity in mature granule cells, as evidenced by increased dendritic length and number of intersections. However, the stimulation did not increase the proliferation of the dentate gyrus progenitor cells. On the contrary, the stimulated mice showed increased dendritic complexity of newly generated neurons. Moreover, 1-Hz rTMS resulted in antidepressant-like effects in the tail suspension test, but it did not affect anxiety-like behaviors. Therefore, our results indicate that 1-Hz rTMS modulates dentate gyrus morphological plasticity in mature and newly generated neurons. Furthermore, our data provide some evidence of an association between the antidepressant-like activity of 1-Hz rTMS and structural plasticity in the hippocampus.

Suggested Citation

  • Marco Cambiaghi & Rosalia Crupi & Erick Larios Bautista & Amir Elsamadisi & Wasib Malik & Helen Pozdniakova & Zhiyong Han & Mario Buffelli & Fortunato Battaglia, 2020. "The Effects of 1-Hz rTMS on Emotional Behavior and Dendritic Complexity of Mature and Newly Generated Dentate Gyrus Neurons in Male Mice," IJERPH, MDPI, vol. 17(11), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:11:p:4074-:d:368509
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/11/4074/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/11/4074/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Antimo Natale & Carmen Concerto & Alessandro Rodolico & Andrea Birgillito & Marina Bonelli & Miriam Martinez & Maria Salvina Signorelli & Antonino Petralia & Carmenrita Infortuna & Fortunato Battaglia, 2022. "Risk Perception among Psychiatric Patients during the COVID-19 Pandemic," IJERPH, MDPI, vol. 19(5), pages 1-12, February.
    2. Wan-Jung Lin & Yu-Ling Chang & Li-Chueh Weng & Feng-Chun Tsai & Huei-Chiun Huang & Shu-Ling Yeh & Kang-Hua Chen, 2022. "Post-Discharge Depression Status for Survivors of Extracorporeal Membrane Oxygenation (ECMO): Comparison of Veno-Venous ECMO and Veno-Arterial ECMO," IJERPH, MDPI, vol. 19(6), pages 1-15, March.
    3. Carmen Concerto & Alessandro Rodolico & Alessia Ciancio & Christian Messina & Antimo Natale & Ludovico Mineo & Fortunato Battaglia & Eugenio Aguglia, 2021. "Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review," IJERPH, MDPI, vol. 19(1), pages 1-21, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:11:p:4074-:d:368509. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.