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Functional Gene Clusters in Global Pathogenesis of Clear Cell Carcinoma of the Ovary Discovered by Integrated Analysis of Transcriptomes

Author

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  • Yueh-Han Hsu

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    School of Medicine, National Yang-Ming University, Taipei 112, Taiwan)

  • Peng-Hui Wang

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
    Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan
    Department of Medical Research, China Medical University Hospital, Taichung 440, Taiwan)

  • Chia-Ming Chang

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    School of Medicine, National Yang-Ming University, Taipei 112, Taiwan)

Abstract

Clear cell carcinoma of the ovary (ovarian clear cell carcinoma (OCCC)) is one epithelial ovarian carcinoma that is known to have a poor prognosis and a tendency for being refractory to treatment due to unclear pathogenesis. Published investigations of OCCC have mainly focused only on individual genes and lack of systematic integrated research to analyze the pathogenesis of OCCC in a genome-wide perspective. Thus, we conducted an integrated analysis using transcriptome datasets from a public domain database to determine genes that may be implicated in the pathogenesis involved in OCCC carcinogenesis. We used the data obtained from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) DataSets. We found six interactive functional gene clusters in the pathogenesis network of OCCC, including ribosomal protein, eukaryotic translation initiation factors, lactate, prostaglandin, proteasome, and insulin-like growth factor. This finding from our integrated analysis affords us a global understanding of the interactive network of OCCC pathogenesis.

Suggested Citation

  • Yueh-Han Hsu & Peng-Hui Wang & Chia-Ming Chang, 2020. "Functional Gene Clusters in Global Pathogenesis of Clear Cell Carcinoma of the Ovary Discovered by Integrated Analysis of Transcriptomes," IJERPH, MDPI, vol. 17(11), pages 1-17, June.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:11:p:3951-:d:366511
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    References listed on IDEAS

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    1. Chen-Yu Huang & Min Cheng & Na-Rong Lee & Hsin-Yi Huang & Wen-Ling Lee & Wen-Hsun Chang & Peng-Hui Wang, 2020. "Comparing Paclitaxel–Carboplatin with Paclitaxel–Cisplatin as the Front-Line Chemotherapy for Patients with FIGO IIIC Serous-Type Tubo-Ovarian Cancer," IJERPH, MDPI, vol. 17(7), pages 1-23, March.
    2. Chao Zhang & Qiang Ren & Wenhui Chang, 2020. "Epidemiological Features and Risk Factors for Acquiring Hepatitis B, Hepatitis C, and Syphilis in HIV-Infected Patients in Shaanxi Province, Northwest China," IJERPH, MDPI, vol. 17(6), pages 1-15, March.
    3. Hao-Ting Chang & Mei-Ling Chiu & Tao-Yuean Wang & Tzu-Chien Chen & Chih-Long Chang & Tsung-Hsien Su & Kuo-Gong Wang & Kung-Liahng Wang & Yuh-Cheng Yang & Jen-Ruei Chen, 2020. "Effect of Chemotherapy, Laparoscopy, and Cytology on Stage IC Ovarian Clear Cell Carcinoma: A Long-Term, Single-Center Study," IJERPH, MDPI, vol. 17(2), pages 1-10, January.
    4. Mee-seon Kim & Eun Hee Lee & Moon-il Park & Jae Seok Lee & Kisu Kim & Mee Sook Roh & Hyoun Wook Lee, 2020. "Utility of Human Papillomavirus Testing for Cervical Cancer Screening in Korea," IJERPH, MDPI, vol. 17(5), pages 1-17, March.
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    1. Chen-Yu Huang & Min Cheng & Na-Rong Lee & Hsin-Yi Huang & Wen-Ling Lee & Wen-Hsun Chang & Peng-Hui Wang, 2020. "Comparing Paclitaxel–Carboplatin with Paclitaxel–Cisplatin as the Front-Line Chemotherapy for Patients with FIGO IIIC Serous-Type Tubo-Ovarian Cancer," IJERPH, MDPI, vol. 17(7), pages 1-23, March.

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