IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i9p1626-d229711.html
   My bibliography  Save this article

Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study

Author

Listed:
  • Liang-Tsai Yeh

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Anesthesiology, Changhua Christian Hospital, Changhua 500, Taiwan
    These authors contributed equally to the work.)

  • Chuan-Yi Tang

    (Department of Computer Science and Information Engineering, Providence University, Taichung City 433, Taiwan
    These authors contributed equally to the work.)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Han-Wei Yeh

    (School of Medicine, Chang Gung University, Taoyuan City 333, Taiwan)

  • Ying-Tung Yeh

    (Graduate School of Dentistry, Chung Shan Medical University, Taichung 402, Taiwan
    School of Dentistry, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Dentistry, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Yu-Hsun Wang

    (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Ming-Chih Chou

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan)

  • Chao-Bin Yeh

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Chi-Ho Chan

    (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    Department of Microbiology and Immunology, Chung Shan Medical University, Taichung 402, Taiwan)

Abstract

This study investigated the association of statin use with sepsis risk in patients with dementia. This retrospective cohort study was conducted in Taiwan by using data from the National Health Insurance Research Database. We identified and enrolled 308 patients with newly diagnosed dementia who used statin after dementia diagnosis. These patients were individually propensity score matched (1:1) according to age, sex, hypertension, hyperlipidemia, diabetes, cerebrovascular disease, renal disease, liver disease, asthma, malignancy, parkinsonism, and dementia drugs used (donepezil, rivastigmine, galantamine, and memantine) with 251 controls (statin non-users). A Cox proportional hazard model was used to estimate the adjusted hazard ratio for sepsis in statin users and non-users. After adjustment for other confounding factors, the incidence of sepsis in statin users was 1.42-fold higher than that in non-users (95% confidence interval = 0.81–2.5). In conclusion, our analysis showed no positive association of sepsis with statin use in patients with dementia.

Suggested Citation

  • Liang-Tsai Yeh & Chuan-Yi Tang & Shun-Fa Yang & Han-Wei Yeh & Ying-Tung Yeh & Yu-Hsun Wang & Ming-Chih Chou & Chao-Bin Yeh & Chi-Ho Chan, 2019. "Association between Statin Use and Sepsis Risk in Patients with Dementia: A Retrospective Cohort Study," IJERPH, MDPI, vol. 16(9), pages 1-10, May.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:9:p:1626-:d:229711
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/9/1626/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/9/1626/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:9:p:1626-:d:229711. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.