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Changes in the Selected Antioxidant Defense Parameters in the Blood of Patients after High Resolution Computed Tomography

Author

Listed:
  • Amira Bryll

    (Department of Radiology, Jagiellonian University Medical College, Kopernika 19, 31-501 Krakow, Poland)

  • Wirginia Krzyściak

    (Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland)

  • Anna Jurczak

    (Department of Pediatric Dentistry, Institute of Dentistry, Jagiellonian University Medical College, Montelupich 4, 31-155 Krakow, Poland)

  • Robert Chrzan

    (Department of Radiology, Jagiellonian University Medical College, Kopernika 19, 31-501 Krakow, Poland)

  • Anna Lizoń

    (Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland)

  • Andrzej Urbanik

    (Department of Radiology, Jagiellonian University Medical College, Kopernika 19, 31-501 Krakow, Poland)

Abstract

Ionizing radiation generated during high resolution computed tomography (HRCT) scanning may have an indirect effect on the mechanisms regulating the oxidative-antioxidant balance in the human body, which is one of the necessary factors ensuring the maintenance of its homeostasis. The aim of the study was to analyze the response of antioxidant systems through the determination of the antioxidant markers in the blood of patients exposed to oxidative stress resulting from the routine HRCT examination of the chest. Blood of 35 people aged 60.77 ± 10.81 taken before and at four time points after the examination constituted the test material. The determination of the total antioxidant capacity expressed as ferric reducing ability of plasma (FRAP) and ferric reducing antioxidant activity and ascorbic acid concentration (FRASC) were performed together with an examination of catalase activity and the concentration of the reduced glutathione. The organism’s response to ionizing radiation was associated with a significant decrease in the antioxidant markers’ levels at all time-points and showed a significant negative correlation depending on the radiation dose. Visible down-regulation of these markers is a response to increased oxidative stress. In light of the obtained results, the measurement of the selected markers of antioxidant defense may be a useful parameter of oxidative stress caused by ionizing radiation.

Suggested Citation

  • Amira Bryll & Wirginia Krzyściak & Anna Jurczak & Robert Chrzan & Anna Lizoń & Andrzej Urbanik, 2019. "Changes in the Selected Antioxidant Defense Parameters in the Blood of Patients after High Resolution Computed Tomography," IJERPH, MDPI, vol. 16(9), pages 1-17, April.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:9:p:1476-:d:226040
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    References listed on IDEAS

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    1. Ernesto Burgio & Prisco Piscitelli & Lucia Migliore, 2018. "Ionizing Radiation and Human Health: Reviewing Models of Exposure and Mechanisms of Cellular Damage. An Epigenetic Perspective," IJERPH, MDPI, vol. 15(9), pages 1-13, September.
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