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Association between Dipeptidyl Peptidase-4 Inhibitors and Allergic Rhinitis in Asian Patients with Diabetes

Author

Listed:
  • Hsin-Hung Chen

    (Institute of Medicine and Public Health, Chung Shan Medical University, Taichung 402, Taiwan
    College of Nursing and Health Sciences, Dayeh University, Changhua 515, Taiwan
    Division of Metabolism Endocrinology, Changhua Christian Hospital, Changhua 500, Taiwan
    Division of Metabolism Endocrinology, Nantou Christian Hospital, Nantou 540, Taiwan)

  • Shang-Yi Li

    (Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua 500, Taiwan
    These authors contributed equally to this work.)

  • Weishan Chen

    (Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan
    College of Medicine, China Medical University, Taichung 404, Taiwan)

  • Chia-Hung Kao

    (Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404, Taiwan
    Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 404, Taiwan
    Department of Bioinformatics and Medical Engineering, Asia University, Taichung 413, Taiwan)

Abstract

In this retrospective study, we attempted to evaluate the association between dipeptidyl peptidase-4 (DPP-4) inhibitors and allergic rhinitis in patients with diabetes. We analyzed the Longitudinal Health Insurance Database 2000 subdatabase. Our study population included patients with type 2 diabetes (ICD-9-CM 250) between 2009 and 2012, and the study groups were DPP-4 inhibitor users and nonusers. Propensity scores were estimated in a multivariable logistic regression model for the analysis of allergic rhinitis (ICD-9-CM 477.9). Each group consisted of 6204 patients. DPP-4 inhibitor users had a reduced risk of allergic rhinitis (aHR = 0.74, 95% confidence interval (CI) = 0.61–0.90) in all stratifications. Among women, DPP-4 inhibitor users had a lower risk of allergic rhinitis (aHR = 0.67, 95% CI = 0.50–0.90). Among patients aged older than 40 years, DPP-4 inhibitor users had a decreased risk of allergic rhinitis (those aged 40–59: aHR = 0.75, 95% CI = 0.56–0.99; those aged ≧60: aHR = 0.73, 95% CI = 0.54–0.97). Among patients with comorbidities, the risk of allergic rhinitis for DPP-4 inhibitor users was 0.73 (95% CI = 0.60–0.90). High-dose (cumulative defined daily dose ≧648mg) DPP-4 inhibitor users had a decreased risk of allergic rhinitis (aHR = 0.23, 95% CI = 0.15–0.35). Our study revealed that Asian patients with diabetes who used DPP-4 inhibitors had decreased risk of allergic rhinitis, especially for DPP-4 inhibitor treatment in patients who were women, were older than 40 years, had higher diabetes severity scores, were taking higher doses of DPP-4 inhibitors, and had diabetes with comorbidities.

Suggested Citation

  • Hsin-Hung Chen & Shang-Yi Li & Weishan Chen & Chia-Hung Kao, 2019. "Association between Dipeptidyl Peptidase-4 Inhibitors and Allergic Rhinitis in Asian Patients with Diabetes," IJERPH, MDPI, vol. 16(8), pages 1-8, April.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:8:p:1323-:d:222334
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