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Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure

Author

Listed:
  • Kerry M. Hena

    (Department of Medicine, New York University, New York, NY 10016, USA)

  • Scarlett Murphy

    (Department of Medicine, New York University, New York, NY 10016, USA)

  • Yian Zhang

    (Department of Population Health and Environmental Medicine, New York University, New York, NY 10016, USA)

  • Yongzhao Shao

    (Department of Population Health and Environmental Medicine, New York University, New York, NY 10016, USA)

  • Angeliki Kazeros

    (Department of Medicine, New York University, New York, NY 10016, USA)

  • Joan Reibman

    (Department of Medicine, New York University, New York, NY 10016, USA
    Department of Population Health and Environmental Medicine, New York University, New York, NY 10016, USA)

Abstract

Background : Sarcoidosis is a granulomatous disease involving intrathoracic and extrathoracic organs. Genetic and environmental factors, such as exposure to World-Trade Center (WTC) dust after 9/11, may play a role in clinical presentation. Characterization of sarcoidosis in community members with exposure to the WTC dust can provide further insight into the relationship between environmental exposure and sarcoidosis. Methods : Patients with documented sarcoidosis were identified in the WTC Environmental Health Center (EHC), a treatment program for community members. Demographic and clinical data were collected from standardized questionnaires and chart review. Organ involvement was assessed with a standard instrument. Results : Among patients in the WTC EHC, 87 were identified with sarcoidosis after 9/11. Sarcoidosis cases were more likely African-American, local workers, and had more respiratory symptoms, compared with non-sarcoidosis WTC EHC patients. Many (46%) had ≥ Scadding stage 3 on chest imaging, and had reduced lung function measures. Extrathoracic involvement was identified in 33/87 (38%) with a diversity of organs involved. Conclusions : WTC-exposed sarcoidosis in community members is often characterized by severe pulmonary disease and a high rate of diverse extrathoracic involvement. Further analysis is required to characterize the course of disease progression or resolution.

Suggested Citation

  • Kerry M. Hena & Scarlett Murphy & Yian Zhang & Yongzhao Shao & Angeliki Kazeros & Joan Reibman, 2019. "Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure," IJERPH, MDPI, vol. 16(7), pages 1-9, April.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:7:p:1291-:d:221702
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    Citations

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    Cited by:

    1. Robert M. Brackbill & Judith M. Graber & William A. (Allen) Robison, 2019. "Editorial for “Long-Term Health Effects of the 9/11 Disaster” in International Journal of Environmental Research and Public Health , 2019," IJERPH, MDPI, vol. 16(18), pages 1-6, September.
    2. Nedim Durmus & Sultan Pehlivan & Yian Zhang & Yongzhao Shao & Alan A. Arslan & Rachel Corona & Ian Henderson & Daniel H. Sterman & Joan Reibman, 2021. "Lung Cancer Characteristics in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 18(5), pages 1-14, March.

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