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Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature

Author

Listed:
  • Salvatore Savasta

    (Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy)

  • Alessandra Rossi

    (Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy)

  • Thomas Foiadelli

    (Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy)

  • Amelia Licari

    (Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy)

  • Anna Maria Elena Perini

    (Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy)

  • Giovanni Farello

    (Pediatric Clinic–Department of Life, Health and Environmental Sciences–Piazzale Salvatore Tommasi 1, 67100 Coppito (AQ), Italy)

  • Alberto Verrotti

    (Pediatric Clinic–Biotechnological and Applied Clinical Sciences Via Vetoio (Coppito 2), 67100 Coppito (AQ), Italy)

  • Gian Luigi Marseglia

    (Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy)

Abstract

Melkersson–Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 published patients. The aetiology of this disease is still unclear. However, genetic factors, as well as alterations in immune functions, infections, and allergic reactions have been postulated. We report three children suffering from MRS and perform a literature review of paediatric cases. Taking into account that clinical and laboratoristical criteria for the diagnosis of MRS are lacking, this syndrome is probably underestimated, and we suggest increasing awareness of such a rare syndrome. Close multidisciplinary follow-up of these children with a team composed by paediatricians, neurologists, neuro-ophthalmologists, dermatologists, and otolaryngologists is crucial to guarantee exhaustive management and treatment success, while minimising relapses.

Suggested Citation

  • Salvatore Savasta & Alessandra Rossi & Thomas Foiadelli & Amelia Licari & Anna Maria Elena Perini & Giovanni Farello & Alberto Verrotti & Gian Luigi Marseglia, 2019. "Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature," IJERPH, MDPI, vol. 16(7), pages 1-13, April.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:7:p:1289-:d:221640
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