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Association of Consecutive Influenza Vaccinations and Pneumonia: A Population-Based Case-Control Study

Author

Listed:
  • Liang-Tsai Yeh

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Anesthesiology, Changhua Christian Hospital, Changhua 50006, Taiwan
    These authors contributed equally to the work.)

  • Chi-Ho Chan

    (Department of Microbiology and Immunology, Chung Shan Medical University, Taichung 40201, Taiwan
    These authors contributed equally to the work.)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Han-Wei Yeh

    (School of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan)

  • Ying-Tung Yeh

    (Graduate Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan
    School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Yu-Hsun Wang

    (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Ming-Chih Chou

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan)

  • Chao-Bin Yeh

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Ying-Hock Teng

    (Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
    Department of Health Policy and Management, Chung Shan Medical University, Taichung 40201, Taiwan)

Abstract

The purpose of this study was to investigate whether individuals receiving influenza vaccines have a lower risk of pneumonia. A nationwide population-based case-control study was conducted using data from the National Health Insurance Research Database in Taiwan. We enrolled 7565 patients each in pneumonia and non-pneumonia groups after diagnosis of patients with chronic pulmonary disease, and these patients were individually age and sex matched in a 1:1 ratio. Using conditional logistic regression analysis, adjusted odds ratios (aORs) were estimated in patients who received influenza vaccination and those who had not previously had pneumonia. Moreover, we also analyzed the interval between vaccination and the onset of pneumonia and the number of vaccinations received by patients. This was compared with patients who never received influenza vaccination. Patients who had received influenza vaccination and had been vaccinated for two consecutive years (aOR = 0.85, confidence interval (CI) = 0.79–0.93 and aOR = 0.75, CI = 0.67–0.85, respectively) showed lower rates of pneumonia occurrence by 15–25%. In conclusion, influenza vaccination significantly reduces the occurrence of pneumonia, especially in individuals who receive vaccination in consecutive years.

Suggested Citation

  • Liang-Tsai Yeh & Chi-Ho Chan & Shun-Fa Yang & Han-Wei Yeh & Ying-Tung Yeh & Yu-Hsun Wang & Ming-Chih Chou & Chao-Bin Yeh & Ying-Hock Teng, 2019. "Association of Consecutive Influenza Vaccinations and Pneumonia: A Population-Based Case-Control Study," IJERPH, MDPI, vol. 16(6), pages 1-9, March.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:6:p:1078-:d:217236
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