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Impact of Gender and Age on Rapid Eye Movement-Related Obstructive Sleep Apnea: A Clinical Study of 3234 Japanese OSA Patients

Author

Listed:
  • Mamiko Mano

    (Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, 1-1 Nagakute, Aichi 4801195, Japan)

  • Tetsuro Hoshino

    (Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, 1-1 Nagakute, Aichi 4801195, Japan)

  • Ryujiro Sasanabe

    (Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, 1-1 Nagakute, Aichi 4801195, Japan)

  • Kenta Murotani

    (Biostatistics Center, Graduate School of Medicine, Kurume University, 67 Asahimachi, Kurume, Fukuoka 8300011, Japan)

  • Atsuhiko Nomura

    (Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, 1-1 Nagakute, Aichi 4801195, Japan)

  • Reiko Hori

    (Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, 1-1 Nagakute, Aichi 4801195, Japan)

  • Noriyuki Konishi

    (Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, 1-1 Nagakute, Aichi 4801195, Japan)

  • Masayo Baku

    (Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, 1-1 Nagakute, Aichi 4801195, Japan)

  • Toshiaki Shiomi

    (Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, 1-1 Nagakute, Aichi 4801195, Japan)

Abstract

Rapid eye movement (REM)-related obstructive sleep apnea (OSA) is characterized by apnea and hypopnea events due to airway collapse occurring predominantly or exclusively during REM sleep. Previous studies have reported that REM-related OSA occurs more commonly in women and younger individuals. However, external validity of this tendency has not been confirmed in a large clinical sample. The objective of this study was to evaluate the effect of gender and age on REM-related OSA after adjustment for several covariates based on their established clinical relationships to gender difference in OSA. A total of 3234 Japanese patients with OSA were enrolled in this study. We confirmed that female sex is an important risk factor for REM-related OSA, as reported by previous studies. Moreover, we showed that women aged over 50 years were at a greater risk than those aged under 50 years. These results suggest that hormonal changes in women might play an important role in REM-related OSA and might reflect its unknown pathophysiological characteristics.

Suggested Citation

  • Mamiko Mano & Tetsuro Hoshino & Ryujiro Sasanabe & Kenta Murotani & Atsuhiko Nomura & Reiko Hori & Noriyuki Konishi & Masayo Baku & Toshiaki Shiomi, 2019. "Impact of Gender and Age on Rapid Eye Movement-Related Obstructive Sleep Apnea: A Clinical Study of 3234 Japanese OSA Patients," IJERPH, MDPI, vol. 16(6), pages 1-9, March.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:6:p:1068-:d:217091
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