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Allergen Sensitization and Asthma Outcomes among World Trade Center Rescue and Recovery Workers

Author

Listed:
  • Belen Rojano

    (Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Erin West

    (Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Emily Ferdermann

    (Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Steven Markowitz

    (Barry Commoner Center for Health and the Environment, Queens College, City University of New York, Queens, New York, NY 11367, USA)

  • Denise Harrison

    (Department of Medicine, New York University School of Medicine, Bellevue Hospital Center, New York, NY 10016, USA)

  • Laura Crowley

    (Division of Occupational and Environmental Medicine, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Paula Busse

    (Division of Allergy and Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Alex D. Federman

    (Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Juan P. Wisnivesky

    (Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

Abstract

A large number of World Trade Center (WTC) rescue and recovery workers are affected by asthma. While physical and mental health comorbidities have been associated with poor asthma control in this population, the potential role of allergen sensitization is unknown. This study examined the association of indoor sensitization and exposure as a risk factor for increased asthma morbidity in WTC workers. We used data from a prospective cohort of 331 WTC workers with asthma. Sensitization to indoor allergens was assessed by measurement of antigen-specific serum immunoglobulin E (IgE) levels. We used validated tools to evaluate the exposure to indoor allergens. Asthma morbidity outcomes included level of control (Asthma Control Questionnaire, ACQ), quality of life (Asthma Quality of Life Questionnaire, AQLQ) and acute resource utilization. The prevalence of sensitization to cat, dog, mouse, dust mite, cockroach, and mold allergens were 33%, 21%, 17%, 40%, 17%, and 17%, respectively. Unadjusted and regression analyses showed no significant relationship between sensitization and increased asthma morbidity ( p > 0.05 for all comparisons), except for sensitization to Aspergillus Fumigatus, cat and mouse epithelium, which were associated with decreased morbidity.

Suggested Citation

  • Belen Rojano & Erin West & Emily Ferdermann & Steven Markowitz & Denise Harrison & Laura Crowley & Paula Busse & Alex D. Federman & Juan P. Wisnivesky, 2019. "Allergen Sensitization and Asthma Outcomes among World Trade Center Rescue and Recovery Workers," IJERPH, MDPI, vol. 16(5), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:5:p:737-:d:209995
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    Citations

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    Cited by:

    1. Robert M. Brackbill & Judith M. Graber & William A. (Allen) Robison, 2019. "Editorial for “Long-Term Health Effects of the 9/11 Disaster” in International Journal of Environmental Research and Public Health , 2019," IJERPH, MDPI, vol. 16(18), pages 1-6, September.
    2. Joan Reibman & Caralee Caplan-Shaw & Yinxiang Wu & Mengling Liu & Milan R. Amin & Kenneth I. Berger & Maria L. Cotrina-Vidal & Angeliki Kazeros & Nedim Durmus & Maria-Elena Fernandez-Beros & Roberta M, 2020. "Characterization of Persistent Uncontrolled Asthma Symptoms in Community Members Exposed to World Trade Center Dust and Fumes," IJERPH, MDPI, vol. 17(18), pages 1-17, September.

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