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Stomach Cancer and Exposure to Talc Powder without Asbestos via Chinese Herbal Medicine: A Population-Based Cohort Study

Author

Listed:
  • Che-Jui Chang

    (Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei 100, Taiwan
    Department of Family Medicine, National Taiwan University Hospital, Taipei 100, Taiwan)

  • Yao-Hsu Yang

    (Department of Traditional Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan
    Health Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi 613, Taiwan
    School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan)

  • Pau-Chung Chen

    (Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei 100, Taiwan
    Department of Public Health, National Taiwan University College of Public Health, Taipei 100, Taiwan
    National Taiwan University Hospital and National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
    Office of Occupational Safety and Health, National Taiwan University College of Medicine, Taipei 100, Taiwan)

  • Hsin-Yi Peng

    (Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei 100, Taiwan
    Department of Public Health, National Taiwan University College of Public Health, Taipei 100, Taiwan
    National Taiwan University Hospital and National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei 100, Taiwan)

  • Yi-Chia Lu

    (Department of Geosciences, National Taiwan University, Taipei 106, Taiwan)

  • Sheng-Rong Song

    (Department of Geosciences, National Taiwan University, Taipei 106, Taiwan)

  • Hsiao-Yu Yang

    (Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei 100, Taiwan
    Department of Public Health, National Taiwan University College of Public Health, Taipei 100, Taiwan
    National Taiwan University Hospital and National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei 100, Taiwan)

Abstract

The present investigation was designed to explore the risk of stomach cancer by oral intake of talc powder without asbestos. We conducted a population-based cohort study on a randomly sampled cohort from Taiwan’s health insurance database, with population of 1,000,000. The study participants were followed up through 2013. The outcome event of interest was the diagnosis of stomach cancer. The exposure of interest was the prescription of talc powder. Cox regression analyses were performed respectively. There were 584,077 persons without talc exposure and 21,575 talc users, 1849 diagnosed with stomach cancer. Persons with exposure of talc had a higher hazard ratio of stomach cancer (adjusted hazard ratio, 2.13; 95% confidence interval (CI), 1.54–2.94; p < 0.001). Classification by cumulative exposure of talc yielded adjusted hazard ratios of stomach cancer of 1.58 (95% CI, 0.79–3.17; p = 0.19) and 2.30 (95% CI, 1.48–3.57; p < 0.001) among persons with high (>21 g) and medium (6–21 g) exposure of talc, as compared to the low-exposure counterparts. Our data demonstrated positive association between increased risk of stomach cancer and oral intake of talc without asbestos. Despite the absence of dose-response effect, there might be a link between stomach cancer and talc.

Suggested Citation

  • Che-Jui Chang & Yao-Hsu Yang & Pau-Chung Chen & Hsin-Yi Peng & Yi-Chia Lu & Sheng-Rong Song & Hsiao-Yu Yang, 2019. "Stomach Cancer and Exposure to Talc Powder without Asbestos via Chinese Herbal Medicine: A Population-Based Cohort Study," IJERPH, MDPI, vol. 16(5), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:5:p:717-:d:209670
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