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Risk of Cancer after Lower Urinary Tract Infection: A Population-Based Cohort Study

Author

Listed:
  • Chia-Hung Huang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Nephrology, Department of Internal Medicine, Lin Shin Hospital, Taichung 402, Taiwan
    These authors contributed equally to the work.)

  • Ying-Hsiang Chou

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    These authors contributed equally to the work.)

  • Han-Wei Yeh

    (School of Medicine, Chang Gung University, Taoyuan City 333, Taiwan)

  • Jing-Yang Huang

    (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Chao-Bin Yeh

    (Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

Abstract

To investigate the association among lower urinary tract infection (UTI), the type and timing of antibiotic usage, and the subsequent risk of developing cancers, especially genitourinary cancers (GUC), in Taiwan. This retrospective population-based cohort study was conducted using 2009–2013 data from the Longitudinal Health Insurance Database. This study enrolled patients who were diagnosed with a UTI between 2010 and 2012. A 1:2 propensity score-matched control population without UTI served as the control group. Multivariate analysis with a multiple Cox regression model was applied to analyze the data. A total of 38,084 patients with UTI were included in the study group, and 76,168 participants without UTI were included in the control group. The result showed a higher hazard ratio of any cancer in both sexes with UTI (for males, adjusted hazard ratio (aHR) = 1.32; 95% confidence interval (CI) = 1.12–1.54; for females, aHR = 1.21; 95% CI = 1.08–1.35). Patients with UTI had a higher probability of developing new GUC than those without UTI. Moreover, the genital organs, kidney, and urinary bladder of men were significantly more affected than those of women with prior UTI. Furthermore, antibiotic treatment for more than 7 days associated the incidence of bladder cancer in men (7–13 days, aHR = 1.23, 95% CI = 0.50–3.02; >14 days, aHR = 2.73, CI = 1.32–5.64). In conclusion, UTI is significantly related to GUC and may serve as an early sign of GUC, especially in the male genital organs, prostate, kidney, and urinary bladder. During UTI treatment, physicians should cautiously prescribe antibiotics to patients.

Suggested Citation

  • Chia-Hung Huang & Ying-Hsiang Chou & Han-Wei Yeh & Jing-Yang Huang & Shun-Fa Yang & Chao-Bin Yeh, 2019. "Risk of Cancer after Lower Urinary Tract Infection: A Population-Based Cohort Study," IJERPH, MDPI, vol. 16(3), pages 1-12, January.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:3:p:390-:d:202056
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    Citations

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    Cited by:

    1. Ying-Cheng Chen & Cheng-Hsun Chuang & Ming-Hong Hsieh & Han-Wei Yeh & Shun-Fa Yang & Chiao-Wen Lin & Ying-Tung Yeh & Jing-Yang Huang & Pei-Lun Liao & Chi-Ho Chan & Chao-Bin Yeh, 2021. "Risk of Mortality and Readmission among Patients with Pelvic Fracture and Urinary Tract Infection: A Population-Based Cohort Study," IJERPH, MDPI, vol. 18(9), pages 1-10, May.

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