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Targeted Transdermal Delivery of Curcumin for Breast Cancer Prevention

Author

Listed:
  • Michele Atlan

    (Breast Cancer Care & Research Fund, Los Angeles, CA 90036, USA)

  • Josh Neman

    (Department of Neurological Surgery, Los Angeles, CA 90033, USA
    Department of Physiology & Neuroscience, Los Angeles, CA 90033, USA
    Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA)

Abstract

N.B. This manuscript is based on the research concept submitted to the “Global Challenge to Prevent Breast Cancer” idea showcase and competition, launched in 2018 by the California Breast Cancer Research Program (CBCRP), which was subsequently selected for publication. The hypothesis, methods, and discussion put forth here are thus proposed concept studies, which could eventually be elucidated in the future. Curcumin is an herbal supplement, shown in preclinical studies to have antioxidant, anti-inflammatory, and antitumoral properties that we believe can be harnessed for breast cancer prevention. However, due to its poor absorption when consumed orally, curcumin’s anticancer effects have not yet been exploited to their full therapeutic potential. Incorporating existing research that focuses on the optimization of curcumin’s bioavailability and the latest transdermal delivery technology, we propose, below, a hypothetical in vivo study to test whether a targeted daily dose of bioavailable curcumin has a cytotoxic effect on cancer cells, potentially reducing the incidence of breast cancer over time. Our ultimate objective is to adopt innovative methods to create curcumin-infused bio-textiles offering transdermal, targeted drug delivery, simply through contact with the skin. We would use this fabric to create disposable bra inserts for an effortless, daily breast cancer prevention regimen for healthy women. It would be essential that the cost of these inserts remain reasonable, but if successful, curcumin is readily available, affordable and non-toxic, and could thus be a preventive measure that would be beneficial for women from all socio-economic backgrounds.

Suggested Citation

  • Michele Atlan & Josh Neman, 2019. "Targeted Transdermal Delivery of Curcumin for Breast Cancer Prevention," IJERPH, MDPI, vol. 16(24), pages 1-8, December.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:24:p:4949-:d:294825
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    References listed on IDEAS

    as
    1. Michal Heger, 2017. "Don't discount all curcumin trial data," Nature, Nature, vol. 543(7643), pages 40-40, March.
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    Cited by:

    1. Chen-Yu Huang & Min Cheng & Na-Rong Lee & Hsin-Yi Huang & Wen-Ling Lee & Wen-Hsun Chang & Peng-Hui Wang, 2020. "Comparing Paclitaxel–Carboplatin with Paclitaxel–Cisplatin as the Front-Line Chemotherapy for Patients with FIGO IIIC Serous-Type Tubo-Ovarian Cancer," IJERPH, MDPI, vol. 17(7), pages 1-23, March.
    2. Nicholas J. Anthis & Marion H. E. Kavanaugh-Lynch, 2020. "The Global Challenge to Prevent Breast Cancer: Surfacing New Ideas to Accelerate Prevention Research," IJERPH, MDPI, vol. 17(4), pages 1-10, February.

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