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The Effects of Anterior Cruciate Ligament Reconstruction on Individual Quadriceps Muscle Thickness and Circulating Biomarkers

Author

Listed:
  • Jae-Ho Yang

    (Department of Kinesiology, Inha University, Incheon 22201, Korea)

  • Seung-Pyo Eun

    (KOSMED Orthopedic Clinic, Seoul 06014, Korea)

  • Dong-Ho Park

    (Department of Kinesiology, Inha University, Incheon 22201, Korea)

  • Hyo-Bum Kwak

    (Department of Kinesiology, Inha University, Incheon 22201, Korea)

  • Eunwook Chang

    (Department of Kinesiology, Inha University, Incheon 22201, Korea)

Abstract

Anterior cruciate ligament reconstruction (ACLR) frequently results in quadriceps atrophy. The present study investigated the effect of ACLR on the muscle thickness of the different constituent muscles of the quadriceps and circulating biomarkers related to muscle atrophy and hypertrophy. Fourteen subjects underwent anterior cruciate ligament reconstruction following injury. Quadriceps muscle thicknesses were measured using ultrasound, and circulating biomarkers in the blood were measured using enzyme-linked immunosorbent assays (ELISAs) at the preoperative visit (PRE) and at two postoperative visits (PO1, PO2) in the early stages post-surgery. Differences between time points were analyzed using one-way repeated measures analysis of variance (ANOVA) tests. The most important finding was that severe muscle atrophy occurred in the vastus intermedius (VI) after ACLR (PRE: 20.45 ± 6.82 mm, PO1: 16.05 ± 6.13 mm, PO2: 13.18 ± 4.7 mm, F = 59.0, p < 0.001). Furthermore, the myostatin level was slightly increased, and IGF-1 was significantly reduced throughout the entire period. Therefore, we suggest that inducing selective hypertrophy in the vastus intermedius during the process of rehabilitation would be important for athletes and individuals who engage in explosive sports. Moreover, inhibiting myostatin level increases and maintaining IGF-1 levels in the early phase of recovery after ACLR to prevent muscle atrophy may provide a pharmaceutical option for rehabilitation after anterior cruciate ligament injury.

Suggested Citation

  • Jae-Ho Yang & Seung-Pyo Eun & Dong-Ho Park & Hyo-Bum Kwak & Eunwook Chang, 2019. "The Effects of Anterior Cruciate Ligament Reconstruction on Individual Quadriceps Muscle Thickness and Circulating Biomarkers," IJERPH, MDPI, vol. 16(24), pages 1-10, December.
  • Handle: RePEc:gam:jijerp:v:16:y:2019:i:24:p:4895-:d:294225
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    Cited by:

    1. Soul Cheon & Joo-Hyun Lee & Hyung-Pil Jun & Yong Woo An & Eunwook Chang, 2020. "Acute Effects of Open Kinetic Chain Exercise Versus Those of Closed Kinetic Chain Exercise on Quadriceps Muscle Thickness in Healthy Adults," IJERPH, MDPI, vol. 17(13), pages 1-11, June.

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