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Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study

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  • Michelle L. Headland

    (School of Pharmacy and Medical Sciences, University of South Australia, Frome Road, Adelaide, SA 5000, Australia
    Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Frome Road, Adelaide, SA 5000, Australia
    Sansom Institute for Health Research University of South Australia, Frome Road, Adelaide, SA 5000, Australia)

  • Peter M. Clifton

    (School of Pharmacy and Medical Sciences, University of South Australia, Frome Road, Adelaide, SA 5000, Australia
    Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Frome Road, Adelaide, SA 5000, Australia
    Sansom Institute for Health Research University of South Australia, Frome Road, Adelaide, SA 5000, Australia)

  • Jennifer B. Keogh

    (School of Pharmacy and Medical Sciences, University of South Australia, Frome Road, Adelaide, SA 5000, Australia
    Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Frome Road, Adelaide, SA 5000, Australia
    Sansom Institute for Health Research University of South Australia, Frome Road, Adelaide, SA 5000, Australia)

Abstract

Fibroblast growth factor-21 (FGF-21), is a protein involved in cell growth and differentiation, development, wound repair and metabolism. Research looking at the impact of weight loss on FGF-21 levels is limited. The objective of this exploratory study was to determine changes in serum FGF-21 levels following weight loss induced by either continuous energy restriction or intermittent energy restriction. A sub cohort of participants who completed a 12-month dietary intervention trial following continuous energy restriction, or a week-on week-off energy restriction pattern, were selected for analysis. FGF-21 levels were not altered by weight loss and were not correlated with body weight or BMI at baseline or 12 months. Weight loss after 12 months either through continuous energy restriction or intermittent energy restriction was −5.9 ± 4.5 and −4.9 ± 3.4 kg, respectively. There was no change in FGF-21 levels, 0.3 ± 0.9 and 0.04 ± 0.2 ng/mL ( p = 0.2). In conclusion, weight loss in healthy overweight or obesity subjects did not affect FGF-21 levels.

Suggested Citation

  • Michelle L. Headland & Peter M. Clifton & Jennifer B. Keogh, 2019. "Effects of Weight Loss on FGF-21 in Human Subjects: An Exploratory Study," IJERPH, MDPI, vol. 16(23), pages 1-5, December.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:23:p:4877-:d:293857
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    References listed on IDEAS

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    1. J. Cliff Yoon & Pere Puigserver & Guoxun Chen & Jerry Donovan & Zhidan Wu & James Rhee & Guillaume Adelmant & John Stafford & C. Ronald Kahn & Daryl K. Granner & Christopher B. Newgard & Bruce M. Spie, 2001. "Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1," Nature, Nature, vol. 413(6852), pages 131-138, September.
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