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Mood Disorders in Levothyroxine-Treated Hypothyroid Women

Author

Listed:
  • Benjamín Romero-Gómez

    (Hospital El Tomillar de Sevilla, Servicio Andaluz de Salud (SAS), 41500 Alcalá de Guadaira, Spain)

  • Paula Guerrero-Alonso

    (Centro de Salud Najera, Servicio Rioja Salud, 26300 Najera, Spain)

  • Juan Manuel Carmona-Torres

    (Facultad de Fisioterapia y Enfermería y Fisioterapia de Toledo, Universidad de Castilla la Mancha, 45005 Toledo, Spain
    Grupo de Investigación Multidisciplinar en Cuidados, Universidad de Castilla la Mancha, 45005 Toledo, Spain
    Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain)

  • Blanca Notario-Pacheco

    (Facultad de Enfermería de Cuenca, Universidad de Castilla la Mancha, 16071 Cuenca Toledo, Spain
    Grupo de Investigación CESS, Universidad de Castilla la Mancha, 16071 Cuenca, Spain)

  • Ana Isabel Cobo-Cuenca

    (Facultad de Fisioterapia y Enfermería y Fisioterapia de Toledo, Universidad de Castilla la Mancha, 45005 Toledo, Spain
    Grupo de Investigación Multidisciplinar en Cuidados, Universidad de Castilla la Mancha, 45005 Toledo, Spain
    Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain)

Abstract

Background : Hypothyroidism has several symptoms (weight gain, arrhythmias, mood changes, etc.). The aims of this study were (1) to assess the prevalence of anxiety and depression in levothyroxine-treated hypothyroid women and in women without hypothyroidism; (2) to identify variables associated with anxiety and depression. Methods : A case-control study was performed with 393 women. Case-group: 153 levothyroxine-treated hypothyroid women. Control-group: 240 women without hypothyroidism. Convenience sampling. Instrument: The Hamilton Hospital Anxiety and Depression Scale (HADS), and a sociodemographic questionnaire. Results : The prevalence of anxiety in levothyroxine-treated hypothyroid women was higher than in women without hypothyroidism (29.4% vs. 16.7%, χ 2 p < 0.001). The prevalence of depression in the case group was higher than in the control group (13.1% vs. 4.6%, χ 2 p < 0.001). Levothyroxine-treated hypothyroid women were more likely to have anxiety (OR = 2.08, CI: 1.28–3.38) and depression (OR = 3.13, IC = 1.45–6.45). Conclusion : In spite of receiving treatment with levothyroxine, women with hypothyroidism are more likely to have depression and anxiety. Health professionals need to assess the mood of women with hypothyroidism. Although levothyroxine is a good treatment for the symptoms of hypothyroidism, it may not be enough to prevent development or persistence of depression and anxiety by itself.

Suggested Citation

  • Benjamín Romero-Gómez & Paula Guerrero-Alonso & Juan Manuel Carmona-Torres & Blanca Notario-Pacheco & Ana Isabel Cobo-Cuenca, 2019. "Mood Disorders in Levothyroxine-Treated Hypothyroid Women," IJERPH, MDPI, vol. 16(23), pages 1-13, November.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:23:p:4776-:d:291999
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    Cited by:

    1. Benjamín Romero-Gómez & Paula Guerrero-Alonso & Juan Manuel Carmona-Torres & José Alberto Laredo-Aguilera & Diana Patricia Pozuelo-Carrascosa & Ana Isabel Cobo-Cuenca, 2020. "Sexual Function in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control," IJERPH, MDPI, vol. 17(12), pages 1-10, June.

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