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Prognostic Value of CD1B in Localised Prostate Cancer

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  • Cheng-Hsueh Lee

    (Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
    Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    These authors contributed equally to this work.)

  • Lih-Chyang Chen

    (Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan
    These authors contributed equally to this work.)

  • Chia-Cheng Yu

    (Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
    Department of Urology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
    Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
    These authors contributed equally to this work.)

  • Wen-Hsin Lin

    (Department of Pharmacy, China Medical University, Taichung 404, Taiwan
    These authors contributed equally to this work.)

  • Victor C. Lin

    (Department of Urology, E-Da Hospital, Kaohsiung 824, Taiwan
    School of Medicine for International Students, I-Shou University, Kaohsiung 840, Taiwan)

  • Chao-Yuan Huang

    (Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 100, Taiwan)

  • Te-Ling Lu

    (Department of Pharmacy, China Medical University, Taichung 404, Taiwan)

  • Shu-Pin Huang

    (Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
    Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan)

  • Bo-Ying Bao

    (Department of Pharmacy, China Medical University, Taichung 404, Taiwan
    Sex Hormone Research Center, China Medical University Hospital, Taichung 404, Taiwan
    Department of Nursing, Asia University, Taichung 413, Taiwan)

Abstract

Cluster of differentiation (CD) antigens are cell surface markers used to differentiate haematopoietic cell types. These antigens are present in various malignancies and are reportedly linked to patient prognosis; however, they have not been implemented as prostate cancer progression markers. Here, we aimed to assess the impact of genetic variation in haematopoietic cell CD markers on clinical outcomes in patients with prostate cancer. An association study of 458 patients with prostate cancer was conducted to identify single-nucleotide polymorphisms in 11 candidate CD marker genes associated with biochemical recurrence (BCR) after radical prostatectomy. Identified predictors were further evaluated in an additional cohort of 185 patients. Joint population analyses showed that CD1B rs3181082 is associated with BCR (adjusted hazard ratio 1.42, 95% confidence interval 1.09–1.85, p = 0.010). In addition, rs3181082 overlapped with predicted transcriptional regulatory elements and affected CD1B expression. Furthermore, low CD1B expression correlated with poorer BCR-free survival. Our results indicated that CD1B rs3181082 confers prostate cancer progression and may help improve clinical prognostic stratification.

Suggested Citation

  • Cheng-Hsueh Lee & Lih-Chyang Chen & Chia-Cheng Yu & Wen-Hsin Lin & Victor C. Lin & Chao-Yuan Huang & Te-Ling Lu & Shu-Pin Huang & Bo-Ying Bao, 2019. "Prognostic Value of CD1B in Localised Prostate Cancer," IJERPH, MDPI, vol. 16(23), pages 1-8, November.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:23:p:4723-:d:291245
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    Cited by:

    1. Poon, Charlotte & Haderi, Artes & Roediger, Alexander & Yuan, Megan, 2022. "Should we screen for lung cancer? A 10-country analysis identifying key decision-making factors," Health Policy, Elsevier, vol. 126(9), pages 879-888.

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    Keywords

    CD antigen; prostate cancer; biomarker; prognosis; CD1B;
    All these keywords.

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