IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i23p4680-d290371.html
   My bibliography  Save this article

Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys

Author

Listed:
  • Ka Chun Chong

    (School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China
    Clinical Trials and Biostatistics Laboratory Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518172, China
    These authors contributed equally.)

  • Yan Rui

    (Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310058, China
    These authors contributed equally.)

  • Yan Liu

    (School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China)

  • Tianyuan Zhou

    (School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China)

  • Katherine Jia

    (School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China)

  • Maggie Haitian Wang

    (School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China
    Clinical Trials and Biostatistics Laboratory Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518172, China)

  • Kirran N. Mohammad

    (School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China)

  • Hanqing He

    (Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310058, China)

Abstract

In China, children aged <8 months, who were expected to be protected by maternal antibodies before receiving the first dose of measles vaccine, were the age group with the greatest risk of infection in recent years. In this study, we evaluated whether infants yet to be age-eligible for measles vaccine had a sufficient seropositive level of maternal measles antibodies in 2009 and 2013. Blood samples were collected from infants aged <8 months through population-based serological surveys conducted in Zhejiang, China. Serum levels of immunoglobulin G measles antibodies were quantified using enzyme-linked immunosorbent assay. In 2013, the mean geometric mean titres (GMTs) of infants aged 4 to 8 months were below the seropositivity threshold (<200 mIU/mL), decreasing from 118.6 mIU/mL (95% confidence interval [CI] 83.0, 169.3 mIU/mL) at 4 months to 28.6 mIU/mL (95% CI 15.6, 52.3 mIU/mL) at 7 months. Antibody levels were significantly lower in 2013 than in 2009 starting from 5 months of age. In conclusion, infants aged 4 to 8 months are susceptible to measles due to low levels of maternal measles antibodies. It is thus suggested to provide infants with a supplementary dose on top of the routine schedule, and/or launch catch-up vaccination campaigns among young women.

Suggested Citation

  • Ka Chun Chong & Yan Rui & Yan Liu & Tianyuan Zhou & Katherine Jia & Maggie Haitian Wang & Kirran N. Mohammad & Hanqing He, 2019. "Early Waning of Maternal Measles Antibodies in Infants in Zhejiang Province, China: A Comparison of Two Cross-Sectional Serosurveys," IJERPH, MDPI, vol. 16(23), pages 1-8, November.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:23:p:4680-:d:290371
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/23/4680/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/23/4680/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Luman, E.T. & Barker, L.E. & McCauley, M.M. & Drews-Botsch, C., 2005. "Timeliness of childhood immunizations: A state-specific analysis," American Journal of Public Health, American Public Health Association, vol. 95(8), pages 1367-1374.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Fabio Lugoboni & Raimondo Maria Pavarin & Chiara Resentera & Daniele Gambini, 2015. "Let It “B”? The Role of Hepatitis B Universal Vaccination among Italian Problematic Drug Users," IJERPH, MDPI, vol. 12(4), pages 1-14, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:23:p:4680-:d:290371. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.