IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i22p4352-d284719.html
   My bibliography  Save this article

Early- and Late-Luteal-Phase Estrogen and Progesterone Levels of Women with Premenstrual Dysphoric Disorder

Author

Listed:
  • Ju-Yu Yen

    (Department of Psychiatry, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan
    Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan)

  • Huang-Chi Lin

    (Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan)

  • Pai-Cheng Lin

    (Department of Psychiatry, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan)

  • Tai-Ling Liu

    (Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan)

  • Cheng-Yu Long

    (Department of Obstetrics and Gynecology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan)

  • Chih-Hung Ko

    (Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
    Department of Psychiatry, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan
    Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan)

Abstract

Objective/introduction: The dynamics of ovarian hormone fluctuations during the luteal phase of the menstruation cycle were previously suggested to contribute to the development of premenstrual dysphoric disorder (PMDD) symptoms, but adequate empirical evidence has not been obtained from hormone concentration studies. We prospectively evaluated estrogen and progesterone levels in the early luteal (EL) and late luteal (LL) phases in women with PMDD and the association of these levels with PMDD symptom severity. Methods: 63 women with PMDD and 53 controls without such severe symptoms were evaluated for the estrogen and progesterone levels, and PMDD severity in the EL and LL phases. Results: The results demonstrated that the women with PMDD had a lower EL-phase estrogen level than the controls. Covariant analysis demonstrated that the interaction term between EL-phase estrogen and EL-phase progesterone level was associated with PMDD severity. Among women with lower EL estrogen levels, higher EL-phase progesterone was observed among the women with PMDD versus controls. These results suggest that low EL-phase estrogen level could moderate the provoking effect of EL progesterone in women with PMDD. Overall, these data suggest a possible role of estrogen and progesterone in the development of PMDD symptoms.

Suggested Citation

  • Ju-Yu Yen & Huang-Chi Lin & Pai-Cheng Lin & Tai-Ling Liu & Cheng-Yu Long & Chih-Hung Ko, 2019. "Early- and Late-Luteal-Phase Estrogen and Progesterone Levels of Women with Premenstrual Dysphoric Disorder," IJERPH, MDPI, vol. 16(22), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:22:p:4352-:d:284719
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/22/4352/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/22/4352/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:22:p:4352-:d:284719. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.