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Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?

Author

Listed:
  • Silvan Silva de Araújo

    (Post-Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil)

  • Felipe José Aidar

    (Post-Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
    Post-Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
    Group of Studies and Research of Performance, Sport, Health and Paralympic Sports—GEPEPS, Federal University of Sergipe, São Cristovão, Sergipe 49100-000, Brazil
    Department of Physical Education, Federal University of Sergipe, São Cristóvão, Sergipe 49100-000, Brazil)

  • Dihogo Gama de Matos

    (Group of Studies and Research of Performance, Sport, Health and Paralympic Sports—GEPEPS, Federal University of Sergipe, São Cristovão, Sergipe 49100-000, Brazil
    Institute of Parasitology, McGill University, Montreal, QC H9X 3V9, Canada)

  • Jymmys Lopes dos Santos

    (Post-Graduate Program in Biotechnology, Northeast Network in Biotechnology (RENORBIO), Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil)

  • Lúcio Marques Vieira Souza

    (Post-Graduate Program in Biotechnology, Northeast Network in Biotechnology (RENORBIO), Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil)

  • Albená Nunes da Silva

    (Exercise’s Inflammation and Immunology Laboratory, Sports Center, Federal University of Ouro Preto, Minas Gerais 35400-000, Brazil)

  • Rodrigo Miguel dos Santos

    (Post-Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
    Department of Circulation and Medical Imaging, St. Olav’s Hospital, Norwegian University of Science and Technology (NTNU), NO-0508 Trondheim, Norway)

  • Anderson Carlos Marçal

    (Post-Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil)

  • Daniella Mota Mourão

    (Department of Medical Clinic, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil)

  • Amário Lessa Júnior

    (Department of Physical Education, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil)

  • Geraldo Magela Durães

    (Department of Physical Education, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil)

  • André Luiz Gomes Carneiro

    (Department of Physical Education, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil)

  • Rodrigo Gonçalves da Silva

    (Department of Physical Education, University Funorte of Montes Claros, Montes Claros, MG 39401-089, Brazil)

  • Mauro Martins Teixeira

    (Department of Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil)

  • Charles dos Santos Estevam

    (Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil
    Post-Graduate Program in Biotechnology, Northeast Network in Biotechnology (RENORBIO), Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil)

Abstract

Many species of the genus Croton have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate the effect of a hydroethanolic extract (HEE) from the inner bark of Croton argyrophyllus (Euphorbiaceae) on muscle damage and oxidative stress in rats after high intensity exercise. The animals were divided into four groups: (i) the sedentary group (SV; n = 7), (ii) the exercise vehicle group (EV, n = 7), (iii) the sedentary group HEE (SHG; n = 7) composed of sedentary animals and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.), and (iv) the HEE exercise group (HEE; n = 7) composed of animals submitted to resistance exercise (RE) and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.). In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) test, the HEE showed lower values of inhibition potential (IP%) at 39.79% compared to gallic acid, 87.61%, and lipoperoxidation inhibition at 27.4% (100 µg/mL) or 28.6% (200 µg/mL) ( p < 0.001). There was inhibition in free radicals in vivo. The HEE of C. argyrophyllus partially reduced the biomarkers of oxidative stress in muscle tissue and muscular damage (creatine kinase (CK) and Lactate Dehydrogenase (LDH)) ( p < 0.05) in rats, and in this sense it can be an aid to the recovery process after exhaustive efforts.

Suggested Citation

  • Silvan Silva de Araújo & Felipe José Aidar & Dihogo Gama de Matos & Jymmys Lopes dos Santos & Lúcio Marques Vieira Souza & Albená Nunes da Silva & Rodrigo Miguel dos Santos & Anderson Carlos Marçal & , 2019. "Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?," IJERPH, MDPI, vol. 16(21), pages 1-11, October.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:21:p:4237-:d:282342
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    Citations

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    Cited by:

    1. Victor Machado Reis, 2020. "Effects of Exercise on Biomarkers in Health and Disease: Some New Insights with Special Focus on Extreme Exercise and Healthy Ageing," IJERPH, MDPI, vol. 17(6), pages 1-5, March.
    2. Ayrton Moraes Ramos & Pablo Jorge Marcos-Pardo & Rodrigo Gomes de Souza Vale & Lucio Marques Vieira-Souza & Bruno de Freitas Camilo & Estélio Henrique Martin-Dantas, 2022. "Resistance Circuit Training or Walking Training: Which Program Improves Muscle Strength and Functional Autonomy More in Older Women?," IJERPH, MDPI, vol. 19(14), pages 1-11, July.

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