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QUICK: Quality and Usability Investigation and Control Kit for Mass Spectrometric Data from Detection of Persistent Organic Pollutants

Author

Listed:
  • Wenjing Guo

    (U.S. Food & Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Authors who made equal contributions.)

  • Jeffrey Archer

    (U.S. Food & Drug Administration, Arkansas Laboratory, 3900 NCTR Road, Jefferson, AR 72079, USA
    Authors who made equal contributions.)

  • Morgan Moore

    (U.S. Food & Drug Administration, Arkansas Laboratory, 3900 NCTR Road, Jefferson, AR 72079, USA)

  • Jeffrey Bruce

    (U.S. Food & Drug Administration, Arkansas Laboratory, 3900 NCTR Road, Jefferson, AR 72079, USA)

  • Michelle McLain

    (U.S. Food & Drug Administration, Arkansas Laboratory, 3900 NCTR Road, Jefferson, AR 72079, USA)

  • Sina Shojaee

    (U.S. Food & Drug Administration, Arkansas Laboratory, 3900 NCTR Road, Jefferson, AR 72079, USA)

  • Wen Zou

    (U.S. Food & Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA)

  • Linda A. Benjamin

    (U.S. Food & Drug Administration, Center for Veterinary Medicine, 7500 Standish Place, Rockville, MD 20855, USA)

  • Anthony Adeuya

    (U.S. Food & Drug Administration, Center for Food Safety and Applied Nutrition, 5001 Campus Dr, College Park, MD 20740, USA)

  • Russell Fairchild

    (U.S. Food & Drug Administration, Arkansas Laboratory, 3900 NCTR Road, Jefferson, AR 72079, USA)

  • Huixiao Hong

    (U.S. Food & Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA)

Abstract

Persistent organic pollutants (POPs) cause a significant public and environmental health concern due to their toxicity, long-range transportability, persistence, and bioaccumulation. The US Food and Drug Administration (FDA) has a program to monitor POPs in human and animal foods at ultra-trace levels, using gas chromatography coupled with mass spectrometry (GC–MS). Stringent quality control procedures are practiced within this program, ensuring the reliability and accuracy of these POP results. Due to the complexity of this program’s quality control (QC), the decision-making process for data usability was very time-consuming, upward of three analyst hours for a batch of six extracts. We significantly reduced this time by developing a software kit, written in Python, to evaluate instrument and sample QC, along with data usability. A diverse set of 45 samples were tested using our software, QUICK (Quality and Usability Investigation and Control Kit), that resulted in equivalent results provided by a human reviewer. The software improved the efficiency of the analytical process by reducing the need for user intervention, while simultaneously recognizing a 95% decrease in data reduction time, from 3 hours to 10 minutes.

Suggested Citation

  • Wenjing Guo & Jeffrey Archer & Morgan Moore & Jeffrey Bruce & Michelle McLain & Sina Shojaee & Wen Zou & Linda A. Benjamin & Anthony Adeuya & Russell Fairchild & Huixiao Hong, 2019. "QUICK: Quality and Usability Investigation and Control Kit for Mass Spectrometric Data from Detection of Persistent Organic Pollutants," IJERPH, MDPI, vol. 16(21), pages 1-15, October.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:21:p:4203-:d:281671
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    Citations

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    Cited by:

    1. Aldona Dobrzycka-Krahel & Michał E. Skóra & Marika Malek, 2024. "Human Consumption of Non-Native Species in a Circular Economy: Determination of Persistent Organic Pollutants in the Invasive Signal Crayfish from a Baltic Coastal River and Its Assessment for Consump," Sustainability, MDPI, vol. 16(9), pages 1-14, April.
    2. Wenjing Guo & Bohu Pan & Sugunadevi Sakkiah & Gokhan Yavas & Weigong Ge & Wen Zou & Weida Tong & Huixiao Hong, 2019. "Persistent Organic Pollutants in Food: Contamination Sources, Health Effects and Detection Methods," IJERPH, MDPI, vol. 16(22), pages 1-29, November.

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